Fluorescence photodiagnosis in clinical practice

被引：25

作者：

Moghissi, K. ^{[1
]}

Stringer, M. R. ^{[1
,2
]}

Dixon, Kate ^{[1
]}

机构：

[1] Goole & Dist Hosp, Yorkshire Laser Ctr, Goole DN14 6RX, East Yorkshire, England

[2] Univ Leeds, Inst Microwaves & Photon, Leeds LS2 9JT, W Yorkshire, England

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2008年 / 5卷 / 04期

关键词：

Fluorescence photodiagnosis; Principle of fluorescence imaging;

D O I：

10.1016/j.pdpdt.2009.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fluorescence diagnosis has become an important method of investigation in clinical practice particularly in identification and localisation of pre and early cancerous lesions as well as image guided therapy. The method relies on the principle of differential fluorescence emission between abnormal and normal tissues in response to excitation by a specific wavelength of light within the visible spectrum range. In clinical practice two types of fluorescence diagnostic methods are used, namely autofluorescence and drug-induced fluorescence. The former relies on the differential fluorescence of "native" fluorophores whereas the latter requires a photosensitiser which enhances the differential fluorescence emission of the normal versus the abnormal tissues. Development and advances in fibreoptic, endoscopic instrumentation currently permit fluorescence endoscopy to be carried out in a number of situations. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：235 / 237

页数：3