A multi-center, prospective study on the progression rate of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging to idiopathic normal pressure hydrocephalus

被引：18

作者：

Kimihira, Luna ^{[1
]}

Iseki, Chifumi ^{[1
]}

Takahashi, Yoshimi ^{[1
]}

Sato, Hidenori ^{[1
]}

Kato, Hajime ^{[1
]}

Kazui, Hiroaki ^{[2
]}

Kuriyama, Nagato ^{[3
]}

Nakajima, Madoka ^{[4
]}

Miyajima, Masakazu ^{[4
]}

Endo, Katsuhiro ^{[5
]}

Kobayashi, Yoshio ^{[6
]}

Saegusa, Takashi ^{[7
]}

Takeda, Yasuaki ^{[8
]}

Sato, Shunsuke ^{[9
]}

Tomogane, Yusuke ^{[10
]}

Baba, Toru ^{[11
]}

Miyake, Hiroji ^{[12
]}

Matsumae, Mitsunori ^{[13
]}

Onozuka, Satoshi ^{[14
]}

Murai, Hisayuki ^{[15
]}

Kajimoto, Yoshinaga ^{[16
]}

Kimura, Teruo ^{[17
]}

Kobayashi, Masahito ^{[18
]}

Yamazaki, Masashi ^{[19
]}

Arai, Hajime ^{[4
]}

Kato, Takeo ^{[1
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Internal Med 3, Div Neurol & Clin Neurosci, 2-2-2 Iida Nishi, Yamagata 9909585, Japan

[2] Kochi Univ, Kochi Med Sch, Dept Psychiat, Kochi, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Epidemiol Community Hlth & Med, Kyoto, Japan

[4] Juntendo Univ, Sch Med, Dept Neurosurg, Tokyo, Japan

[5] Masu Mem Hosp, Dept Neurosurg, Fukushima, Japan

[6] Kyorin Univ, Sch Med, Dept Geriatr Med, Tokyo, Japan

[7] Chiba Rosai Hosp, Dept Neurosurg, Chiba, Japan

[8] Japan Community Healthcare Org Tokyo Yamate Med C, Dept Neurosurg, Tokyo, Japan

[9] Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan

[10] Hyogo Coll Med Hosp, Dept Neurosurg, Nishinomiya, Hyogo, Japan

[11] Tohoku Univ, Grad Sch Med, Dept Behav Neurol & Cognit Neurosci, Sendai, Miyagi, Japan

[12] Nishinomiya Kyoritsu Neurosurg Hosp, Dept Neurosurg, Nishinomiya, Hyogo, Japan

[13] Tokai Univ, Sch Med, Dept Neurosurg, Hiratsuka, Kanagawa, Japan

[14] Kawasaki Municipal Kawasaki Hosp, Dept Neurosurg, Kawasaki, Kanagawa, Japan

[15] Chiba Univ Hosp, Dept Neurosurg, Chiba, Japan

[16] Osaka Med Coll Hosp, Dept Neurosurg, Osaka, Japan

[17] Doutou Neurosurg Hosp, Dept Neurosurg, Kitami, Hokkaido, Japan

[18] Saitama Med Univ Hosp, Dept Neurosurg, Saitama, Japan

[19] Hokushin Gen Hosp Nagano Prefectural Federat Agr, Dept Neurol, Nagano, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2020年 / 419卷

关键词：

VASCULAR RISK-FACTORS;

D O I：

10.1016/j.jns.2020.117166

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Our previous community-based study demonstrated that some individuals with AVIM [asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus (iNPH) on magnetic resonance imaging (MRI)] progressed to iNPH in several years. In this hospital-based study, we investigated the progression rate from AVIM to iNPH and its possible predictors. Methods: We conducted a prospective study of participants with AVIM from several medical institutions/hospitals in Japan. AVIM is defined as "asymptomatic ventriculomegaly with features of iNPH on MRI"; in the present study, asymptomatic was defined as "0 (no symptoms) or 1 (presence of only subjective, but not objective, symptoms) on the iNPH Grading Scale (iNPH-GS)." We also measured possible predicting factors for AVIM-to-iNPH progression, including age, sex, body weight, blood pressure, diabetes mellitus, dyslipidemia, history of mental disease/head injury/sinusitis/smoking/alcohol-intake, Evans index, and the presence of DESH (disproportionately enlarged subarachnoid-space hydrocephalus) findings on brain MRI, and analyzed these potential predictive values. Results: In 2012, 93 participants with AVIM were registered and enrolled in the study. Of these, 52 participants were able to be tracked for three years (until 2015). Of the 52 participants, 27 (52%) developed iNPH during the follow-up period (11 definite, 6 probable, and 10 possible iNPH), whereas 25 participants remained asymptomatic in 2015. Among the possible predictive factors examined, the baseline scores of iNPH-GS predicted the AVIM-to-iNPH progression. Conclusions: The multicenter prospective study demonstrated that the progression rate from AVIM to iNPH was similar to 17% per year, and the baseline scores of iNPH-GS predicted the AVIM-to-iNPH progression.

引用

页数：5

共 18 条

[1] SYMPTOMATIC OCCULT HYDROCEPHALUS WITH NORMAL CEREBROSPINAL-FLUID PRESSURE - A TREATABLE SYNDROME [J].

ADAMS, RD ;

FISHER, CM ;

HAKIM, S ;

OJEMANN, RG ;

SWEET, WH .

NEW ENGLAND JOURNAL OF MEDICINE, 1965, 273 (03) :117-&

[2] RISK-FACTORS FOR THE SYNDROME OF VENTRICULAR ENLARGEMENT WITH GAIT APRAXIA (IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS) - A CASE-CONTROL STUDY [J].

CASMIRO, M ;

DALESSANDRO, R ;

CACCIATORE, FM ;

DAIDONE, R ;

CALBUCCI, F ;

LUGARESI, E .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1989, 52 (07) :847-852

[3] Normal pressure hydrocephalus in the spectrum of neurological complications of systemic lupus erythematosus [J].

de Oliveira, Fabricio Ferreira ;

Marchiori Cardoso, Tania Aparecida ;

Sampaio-Barros, Percival Degrava ;

Damasceno, Benito Pereira .

NEUROLOGICAL SCIENCES, 2013, 34 (06) :1009-1013

[4] IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS AND SYSTEMIC HYPERTENSION [J].

GRAFFRADFORD, NR ;

GODERSKY, JC .

NEUROLOGY, 1987, 37 (05) :868-871

[5]

Hakim S, 1965, J Neurol Sci, V2, P307, DOI 10.1016/0022-510X(65)90016-X

[6] Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: A prospective study in a Japanese population [J].

Iseki, Chifumi ;

Kawanami, Toru ;

Nagasawa, Hikaru ;

Wada, Manabu ;

Koyama, Shingo ;

Kikuchi, Kenji ;

Arawaka, Shigeki ;

Kurita, Keiji ;

Daimon, Makoto ;

Mori, Etsuro ;

Kato, Takeo .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 277 (1-2) :54-57

[7] Agreement study on gait assessment using a video-assisted rating method in patients with idiopathic normal-pressure hydrocephalus [J].

Ishikawa, Masatsune ;

Yamada, Shigeki ;

Yamamoto, Kazuo .

PLOS ONE, 2019, 14 (10)

[8]

Israelsson H, 2017, NEUROLOGY, V88, P577, DOI 10.1212/WNL.0000000000003583

[9] Vascular factors in suspected normal pressure hydrocephalus A population-based study [J].

Jaraj, Daniel ;

Agerskov, Simon ;

Rabiei, Katrin ;

Marlow, Thomas ;

Jensen, Christer ;

Guo, Xinxin ;

Kern, Silke ;

Wikkelso, Carsten ;

Skoog, Ingmar .

NEUROLOGY, 2016, 86 (07) :592-599

[10] Investigation of the freely available easy-to-use software 'EZR' for medical statistics [J].

Kanda, Y. .

BONE MARROW TRANSPLANTATION, 2013, 48 (03) :452-458

← 1 2 →