Spatio- Temporal Patterning in Primary Motor Cortex at Movement Onset

被引:12
作者
Best, Matthew D. [1 ]
Suminski, Aaron J. [2 ,4 ]
Takahashi, Kazutaka [2 ]
Brown, Kevin A. [3 ]
Hatsopoulos, Nicholas G. [1 ,2 ]
机构
[1] Univ Chicago, Comm Computat Neurosci, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA
[3] NYU, Ctr Neural Sci, New York, NY 10003 USA
[4] Milwaukee Sch Engn, Dept Elect Engn & Comp Sci, Milwaukee, WI 53202 USA
关键词
local field potentials; movement initiation; sequential engagement; spatio-temporal patterning; TRANSCRANIAL MAGNETIC STIMULATION; LOCAL-FIELD POTENTIALS; TO-GRASP MOVEMENTS; INTRINSIC CONNECTIONS; SENSORIMOTOR CORTEX; FORELIMB MOVEMENT; PRECENTRAL CORTEX; RHESUS MACAQUES; ARM MOVEMENTS; AWAKE MONKEYS;
D O I
10.1093/cercor/bhv327
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Voluntary movement initiation involves the engagement of large populations of motor cortical neurons around movement onset. Despite knowledge of the temporal dynamics that lead to movement, the spatial structure of these dynamics across the cortical surface remains unknown. In data from 4 rhesus macaques, we show that the timing of attenuation of beta frequency local field potential oscillations, a correlate of locally activated cortex, forms a spatial gradient across primary motor cortex (MI). We show that these spatio-temporal dynamics are recapitulated in the engagement order of ensembles of MI neurons. We demonstrate that these patterns are unique to movement onset and suggest that movement initiation requires a precise spatio-temporal sequential activation of neurons in MI.
引用
收藏
页码:1491 / 1500
页数:10
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