Prognostic Impact of Peripheral Blood T-Cell Subsets at the Time of Diagnosis on Survival in Patients with Diffuse Large B-Cell Lymphoma

被引:9
|
作者
Shin, Ho-Jin [1 ]
Kim, Do-Young [1 ]
Chung, JooSeop [1 ]
Shin, Kyung-Hwa [2 ]
Lee, Hyungi [3 ]
机构
[1] Pusan Natl Univ Hosp, Sch Med, Med Res Inst, Dept Internal Med,Div Hematol Oncol, Busan, South Korea
[2] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Lab Med, Busan, South Korea
[3] Pusan Natl Univ Hosp, Clin Trial Ctr, Busan, South Korea
关键词
Diffuse large B-cell lymphoma; T-cell subsets; Peripheral blood; Survival; NATURAL-KILLER-CELLS; ABSOLUTE LYMPHOCYTE; COUNT; CHEMOTHERAPY; CHOP;
D O I
10.1159/000510912
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: The effects of lymphocyte subtypes, including helper (Th), natural killer (NK), and regulatory (Treg) cells, and other T-cell subtypes on treatment outcomes in diffuse large B-cell lymphoma (DLBCL) patients are not clearly established. Methods: Among 151 consecutive patients diagnosed with DLBCL, we collected peripheral blood samples at diagnosis from 91 patients who received at least 1 cycle of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab) chemotherapy and analyzed lymphocyte subsets by flow cytometry. Results: DLBCL patients had a higher proportion of CD4(+)CD25(+) Treg (p < 0.001) and lower absolute lymphocyte count than those of healthy controls. Lymphopenia at diagnosis was associated with advanced-stage disease (p = 0.001), a high-intermediate/high-risk International Prognostic Index (IPI) (p < 0.001), and older age (p = 0.060). High-intermediate/high-risk IPI, high proportion of CD3(+)CD4(+) Th cells, and extranodal site >= 2 correlated with unfavorable prognostic factors for survival. High proportion of Th cells was associated with fewer cytotoxic T cells and NK cells at the time of diagnosis. Conclusion: This study showed an association between circulating lymphocyte subsets including Th cells, Tregs, and NK cells and clinical outcomes in DLBCL; however, further confirmation is needed via prospective trials.
引用
收藏
页码:427 / 437
页数:11
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