Star-Shaped Polypeptides: Synthesis and Opportunities for Delivery of Therapeutics

被引：64

作者：

Byrne, Mark ^{[1
]}

Murphy, Robert ^{[1
]}

Kapetanakis, Antonios ^{[1
]}

Ramsey, Joanne ^{[2
]}

Cryan, Sally-Ann ^{[2
,3
,4
]}

Heise, Andreas ^{[1
,2
]}

机构：

[1] Dublin City Univ Glasnevin, Sch Chem Sci, Dublin 9, Ireland

[2] Royal Coll Surgeons Ireland, Sch Pharm, Dublin 2, Ireland

[3] Royal Coll Surgeons Ireland, Tissue Engn Res Grp, Dublin 2, Ireland

[4] Univ Dublin Trinity Coll, Trin Ctr Bioengn, Dublin 2, Ireland

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2015年 / 36卷 / 21期

基金：

爱尔兰科学基金会;

关键词：

polypeptides; N-carboxyanhydride; star polypeptides; drug delivery; gene delivery; ACID-N-CARBOXYANHYDRIDES; RADIAL-GROWTH POLYMERIZATION; BLOCK-COPOLYMER MICELLES; NONVIRAL GENE DELIVERY; DRUG-DELIVERY; SECONDARY STRUCTURE; DENDRIMERS; POLYMERS; COPOLYPEPTIDES; NANOPARTICLE;

D O I：

10.1002/marc.201500300

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Significant advances in the synthesis of polypeptides by N-carboxyanhydride (NCA) polymerisation over the last decade have enabled the design of advanced polypeptide architectures such as star-shaped polypeptides. These materials combine the functionality offered by amino acids with the flexibility of creating stable nanoparticles with adjustable cargo space for therapeutic delivery. This review highlights recent advances in the synthesis of star polypeptides by NCA polymerisation followed by a critical review of the applications of this class of polymer in the delivery of therapeutic agents. This includes examples of traditional small-molecule drugs as well as the emerging class of biologics such as genetic therapeutics (gene delivery).

引用

页码：1862 / 1876

页数：15

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