Development and validation of an HPLC method to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids

被引：35

作者：

Frischmann, Matthias ^{[1
]}

Spitzer, Johanna ^{[1
]}

Fuenfrocken, Michael ^{[2
]}

Mittelmaier, Stefan ^{[1
]}

Deckert, Melanie ^{[1
]}

Fichert, Thomas ^{[2
]}

Pischetsrieder, Monika ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91052 Erlangen, Germany

[2] Fresenius Med Care, D-66606 St Wendel, Germany

来源：

BIOMEDICAL CHROMATOGRAPHY | 2009年 / 23卷 / 08期

关键词：

3,4-dideoxyglucosone-3-ene (3,4-DGE); peritoneal dialysis fluid (PD fluid); HPLC; glucose degradation products (GDP); GLUCOSE DEGRADATION-PRODUCTS; GLYCATION END-PRODUCTS; ALPHA-DICARBONYL COMPOUNDS; MESOTHELIAL CELLS; HEAT-STERILIZATION; MAILLARD REACTION; PD FLUIDS; 3-DEOXYGLUCOSONE; MEMBRANE; EXPRESSION;

D O I：

10.1002/bmc.1194

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method was developed and validated to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids by high-performance liquid chromatography with UV detection after derivatization with o-phenylenediamine. The advantages of this method compared with direct HPLC analysis are (i) the possibility of quantifying 3,4-dideoxyglucosone-3-ene simultaneously together with other glucose degradation products, (ii) the compatibility of the method with MS detection for unequivocal identification of the analyte and (iii) a bathochromic shift of the UV absorbance maximum which leads to higher selectivity. The validated method was used to measure 3,4-dideoxyglucosone-3-ene concentrations additionally to the glucose degradation products 3-deoxyglucosone, methylglyoxal, glyoxal, 5-hydroxymethylfurfural, 2-furaldehyde, formaldehyde and acetaldehyde in 19 commercial products for peritoneal dialysis. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：843 / 851

页数：9

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