Development and validation of an HPLC method to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids

被引：35

作者：

Frischmann, Matthias ^{[1
]}

Spitzer, Johanna ^{[1
]}

Fuenfrocken, Michael ^{[2
]}

Mittelmaier, Stefan ^{[1
]}

Deckert, Melanie ^{[1
]}

Fichert, Thomas ^{[2
]}

Pischetsrieder, Monika ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91052 Erlangen, Germany

[2] Fresenius Med Care, D-66606 St Wendel, Germany

来源：

BIOMEDICAL CHROMATOGRAPHY | 2009年 / 23卷 / 08期

关键词：

3,4-dideoxyglucosone-3-ene (3,4-DGE); peritoneal dialysis fluid (PD fluid); HPLC; glucose degradation products (GDP); GLUCOSE DEGRADATION-PRODUCTS; GLYCATION END-PRODUCTS; ALPHA-DICARBONYL COMPOUNDS; MESOTHELIAL CELLS; HEAT-STERILIZATION; MAILLARD REACTION; PD FLUIDS; 3-DEOXYGLUCOSONE; MEMBRANE; EXPRESSION;

D O I：

10.1002/bmc.1194

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method was developed and validated to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids by high-performance liquid chromatography with UV detection after derivatization with o-phenylenediamine. The advantages of this method compared with direct HPLC analysis are (i) the possibility of quantifying 3,4-dideoxyglucosone-3-ene simultaneously together with other glucose degradation products, (ii) the compatibility of the method with MS detection for unequivocal identification of the analyte and (iii) a bathochromic shift of the UV absorbance maximum which leads to higher selectivity. The validated method was used to measure 3,4-dideoxyglucosone-3-ene concentrations additionally to the glucose degradation products 3-deoxyglucosone, methylglyoxal, glyoxal, 5-hydroxymethylfurfural, 2-furaldehyde, formaldehyde and acetaldehyde in 19 commercial products for peritoneal dialysis. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：843 / 851

页数：9

共 34 条

[1] DEGRADATION OF CARBOHYDRATES .3. UNSATURATED HEXOSONES
ANET, EFL
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1962, 15 (03) : 503 - &
[2] ANET EFLJ, 1964, ADV CARBOHYD CHEM, V19, P181
[3] Formation of α-dicarbonyl compounds in beer during storage of Pilsner
Bravo, Adriana
Herrera, Julio C.
Scherer, Erika
Ju-Nam, Yon
Ruebsam, Heinrich
Madrid, Jorge
Zufall, Carsten
Rangel-Aldao, Rafael
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (11) : 4134 - 4144
[4] Erixon M, 2004, PERITON DIALYSIS INT, V24, P392
[5] Erixon M, 2006, PERITON DIALYSIS INT, V26, P490
[6] Detection of α-dicarbonyl compounds in Maillard reaction systems and in vivo
Glomb, MA
Tschirnich, R
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (11) : 5543 - 5550
[7] Accumulation of advanced glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration
Honda, K
Nitta, K
Horita, S
Yumura, W
Nihei, H
Nagai, R
Ikeda, K
Horiuchi, S
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (06) : 1541 - 1549
[8] IMMUNOSUPPRESSIVE EFFECTS OF 3,4-DIDEOXYGLUCOSONE-3-ENE, AND INTERMEDIATE IN THE MAILLARD REACTION
KATO, F
MIZUKOSHI, S
AOYAMA, Y
MATSUOKA, H
TANAKA, H
NAKAMURA, K
TSUKAMOTO, M
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1994, 42 (09) : 2068 - 2073
[9] Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products
Lai, KN
Leung, JCK
Chan, LYY
Li, FFK
Tang, SCW
Lam, MF
Tse, KC
Yip, TP
Chan, TM
Wieslander, A
Vlassara, H
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (03) : 466 - 475
[10] Lee HY, 2005, PERITON DIALYSIS INT, V25, P248

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