Degraded and oxetane-bearing limonoids from the roots of Melia azedarach

被引：27

作者：

Fukuyama, Yoshiyasu ^{[1
]}

Nakaoka, Momoko ^{[1
]}

Yamamoto, Tomoko ^{[1
]}

Takahashi, Hironobu ^{[1
]}

Minami, Hiroyuki ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Inst Pharmacognosy, Yamashiro, Tokushima 7708514, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 08期

关键词：

Melia azedarach; limonoid; fraxinellone; azedarachin; brine shrimp lethality; cytotoxicity;

D O I：

10.1248/cpb.54.1219

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Brine shrimp lethality test (BST)-guided fractionation of a methanol extract of the roots of Melia azedarach resulted in the isolation of two new limonoids, 9 alpha-hydroxy-12 alpha-acetoxyfraxinellone (1) and 7,14-epoxyazedarachin B (2), together with the known compounds, 12 alpha-hydroxyfraxinellone (4), 9 alpha-hydroxyfraxinellone (5), azedarachin B (6), and neoazedarachin B (7). The structures of 1 and 2 were elucidated by analysis of spectroscopic data and comparison of their NMR data with those of the known compounds. Compounds 1, 2 and 47 exhibited significant activity in the BST, in particular, azedarachin B (6) showed remarkable BST activity with an LC50 value of 0.0098 mu M.

引用

页码：1219 / 1222

页数：4

共 18 条

[1] CYTOTOXIC LIMONOIDS FROM MELIA AZEDARACH VAR JAPONICA [J].