Quantifying the shifting landscape of B cell immunodominance

被引：5
作者：
Dale, Gordon A. [1 ,2 ]
Shartouny, Jessica R. [1 ,2 ]
Jacob, Joshy [1 ,2 ]
机构：
[1] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
[2] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA
来源：
NATURE IMMUNOLOGY | 2017年 / 18卷 / 04期
关键词：
ANTIBODY-RESPONSES; INFLUENZA VACCINE; VIRUSES; HUMANS;
D O I：
10.1038/ni.3695
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.
引用
收藏
页码：367 / 368
页数：2
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