Hplc determination of clobetasol propionate in cosmetic products

被引：15

作者：

Gagliardi, L

De Orsi, D

Manna, F ^{[1
]}

Tonelli, D

机构：

[1] Univ La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, Rome, Italy

[2] Univ Bologna, Dipartimento Chim Fis & Inorgan, I-40136 Bologna, Italy

[3] Ist Super Sanita, Lab Chim Farmaco, I-00161 Rome, Italy

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2000年 / 23卷 / 03期

关键词：

D O I：

10.1081/JLC-100101456

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and rapid HPLC method for the determination of clobetasol 17-propionate in cosmetic formulations, with antidranduff and antiseborrheic activity, has been developed. The chromatographic separation was carried out on a 5 mu m Purospher-Lichrocart column using water-acetonitrile (40:60, v/v) as the mobile phase and UV detection at 237 nm. The extraction procedure has been validated analysing samples spiked with known amounts of the active principle. The recoveries were greater than 94% and the reproducibility was within 3.0%.

引用

页码：355 / 362

页数：8

共 13 条

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[3]

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