Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran

被引：56
作者：
Ghiassi-Nejad, M
Zekeri, F
Assaei, RG
Kariminia, A
机构：
[1] INRA, NRPD, Radiobiol & Biol Dosimetry Div, Tehran, Iran
[2] Tarbiat Modarres Univ, Dept Biophys, Tehran, Iran
[3] Inst Pasteur, Dept Immunol, Tehran, Iran
来源：
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY | 2004年 / 74卷 / 1-3期
关键词：
high level natural radiation; immune parameters; cytogenetic; chromosome aberration;
D O I：
10.1016/j.jenvrad.2003.12.001
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Ramsar, a northern coastal city of Iran, overlooking the Caspian Sea, has some high level natural radiation areas (HLNRAs) as well as over 50 hot springs with low and high radium contents used as spas by the public and vacationers. The average whole body dose received by population in these areas is about 5 times higher than the normal background radiation level. Studies on the long-term effects of high level natural radioactivity on some immunological and cytogenetical parameters, in the Ramsar inhabitants are summarized in this paper. Our results showed a significant increase of CD69 expression on TCD4+ stimulated cells (P < 0.004) and a significant increase of total serum IgE (P < 0.05), and also higher incidence of stable and unstable chromosomal aberrations in the HLNRA group compared to the control group with normal background radiation (P < 0.05).Other humoral immune parameters, did not show significant differences between the two groups. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：107 / 116
页数：10
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