Identification of virus-encoded microRNAs

被引：1220

作者：

Pfeffer, S

Zavolan, M

Grässer, FA

Chien, MC

Russo, JJ

Ju, JY

John, B

Enright, AJ

Marks, D

Sander, C

Tuschl, T

机构：

[1] Rockefeller Univ, Lab RNA Mol Biol, New York, NY 10021 USA

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[3] Univ Klin Homburg, Inst Mikrobiol & Hyg, Abt Virol, D-66421 Homburg, Germany

[4] Columbia Univ, Columbia Genome Ctr, New York, NY 10032 USA

[5] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10021 USA

来源：

SCIENCE | 2004年 / 304卷 / 5671期

关键词：

D O I：

10.1126/science.1096781

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.

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页码：734 / 736

页数：3

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