Enantioselective organocatalytic tandem Michael-aldol reactions: One-pot synthesis of chiral thiochromenes

被引：374
作者：
Wang, Wei [1 ]
Li, Hao [1 ]
Wang, Jian [1 ]
Zu, Liansuo [1 ]
机构：
[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 32期
关键词：
D O I：
10.1021/ja063328m
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds. Copyright © 2006 American Chemical Society.
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收藏
页码：10354 / 10355
页数：2
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