Identification and Characterization of Solid-State Nature of 2-Chloromandelic Acid

被引：21

作者：

He, Quan ^{[1
]}

Zhu, Jesse ^{[1
]}

Gomaa, Hassan ^{[1
]}

Jennings, Michael ^{[2
]}

Rohani, Sohrab ^{[1
]}

机构：

[1] Univ Western Ontario London, Dept Chem & Biochem Engn, London, ON N6G 4R3, Canada

[2] Univ Western Ontario, Dept Chem, London, ON N6A 5B9, Canada

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 98卷 / 05期

关键词：

2-chloromandelic acid; racemate; enantiomer; conglomerate; differential scanning calorimetry; melting point diagram; crystal structure; PHASE-DIAGRAM; CHIRAL DRUGS; CRYSTALLIZATION; ENANTIOMERS; CHROMATOGRAPHY; OPTIMIZATION; POLYMORPHISM; SOLUBILITY; RESOLUTION; IBUPROFEN;

D O I：

10.1002/jps.21560

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P2(1)/c. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:1.835-1844, 2009

引用

页码：1835 / 1844

页数：10

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