DNA-Decorated Luminescent Vesicles as Drug Carriers

被引：8
作者：
Thelu, Hari Veera Prasad [1 ]
Albert, Shine K. [1 ]
Golla, Murali [1 ]
Krishnan, Nithiyanandan [1 ]
Yamijala, Santosh Bhargav [2 ]
Nair, Sreeja V. [2 ]
Srinivasula, S. Murty [2 ]
Varghese, Reji [1 ]
机构：
[1] Indian Inst Sci Educ & Research Thiruvananthapura, Sch Chem, CET Campus, Trivandrum 695016, Kerala, India
[2] IISER TVM, Sch Biol, Thiruvananthapuram, Kerala, India
来源：
CHEMISTRYSELECT | 2016年 / 1卷 / 17期
关键词：
DNA nanotechnology; supramolecular chemistry; drug delivery; vesicles; fluorescence; BLOCK-COPOLYMER; SUPRAMOLECULAR ASSEMBLIES; HYBRID AMPHIPHILES; CELLULAR UPTAKE; NUCLEIC-ACIDS; DELIVERY; NANOPARTICLES; NANOMATERIALS; NONCOVALENT; MORPHOLOGY;
D O I：
10.1002/slct.201600897
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA based spherical nanostructures is one of the promising nanocarriers for drug delivery applications because of their excellent biocompatibility and unique structural features of DNA. Herein, we report the amphiphilicity driven self-assembly of DNA-phenyleneethynylene based amphiphile into luminescent vesicles and their cellular uptake toward HeLa cell. Spectroscopic and microscopic analyses reveal the self-assembly of this class of amphiphiles into vesicular nanostructures with corona made of DNA and a functional hydrophobic membrane. Vesicles exhibit promising cell permeability.
引用
收藏
页码：5389 / 5396
页数：8
相关论文
共 73 条
[51]   Strategies to create hierarchical self-assembled structures via cooperative non-covalent interactions [J].
Rest, Christina ;
Kandanelli, Ramesh ;
Fernandez, Gustavo .
CHEMICAL SOCIETY REVIEWS, 2015, 44 (08) :2543-2572
[52]   Multiple CH•••O interactions involving glycol chains as driving force for the self-assembly of amphiphilic Pd(II) complexes [J].
Rest, Christina ;
Martin, Anja ;
Stepanenko, Vladimir ;
Allampally, Naveen Kumar ;
Schmidt, David ;
Fernandez, Gustavo .
CHEMICAL COMMUNICATIONS, 2014, 50 (87) :13366-13369
[53]   Self-Assembly and (Hydro)gelation Triggered by Cooperative π-π and Unconventional C-H•••X Hydrogen Bonding Interactions [J].
Rest, Christina ;
Mayoral, Maria Jose ;
Fucke, Katharina ;
Schellheimer, Jennifer ;
Stepanenko, Vladimir ;
Fernandez, Gustavo .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (03) :700-705
[54]   Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology [J].
Sapsford, Kim E. ;
Algar, W. Russ ;
Berti, Lorenzo ;
Gemmill, Kelly Boeneman ;
Casey, Brendan J. ;
Oh, Eunkeu ;
Stewart, Michael H. ;
Medintz, Igor L. .
CHEMICAL REVIEWS, 2013, 113 (03) :1904-2074
[55]   Supramolecular assemblies from amphiphilic homopolymers: Testing the scope [J].
Savariar, Elamprakash N. ;
Aathimanikandan, Sivakumar V. ;
Thayumanavan, S. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (50) :16224-16230
[56]  
Skwarczynski M., 2010, ANGEW CHEM, V122, P5878
[57]   Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System [J].
Skwarczynski, Mariusz ;
Zaman, Mehfuz ;
Urbani, Carl N. ;
Lin, I-Chun ;
Jia, Zhongfan ;
Batzloff, Michael R. ;
Good, Michael F. ;
Monteiro, Michael F. ;
Toth, Istvan .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (33) :5742-5745
[58]  
Soussan E., 2009, ANGEW CHEM, V121, P280
[59]   Drug Delivery by Soft Matter: Matrix and Vesicular Carriers [J].
Soussan, Elodie ;
Cassel, Stephanie ;
Blanzat, Muriel ;
Rico-Lattes, Isabelle .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (02) :274-288
[60]   Smart Lipids for Programmable Nanomaterials [J].
Thompson, Matthew P. ;
Chien, Miao-Ping ;
Ku, Ti-Hsuan ;
Rush, Anthony M. ;
Gianneschi, Nathan C. .
NANO LETTERS, 2010, 10 (07) :2690-2693
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