DNA-Decorated Luminescent Vesicles as Drug Carriers

被引：8
作者：
Thelu, Hari Veera Prasad [1 ]
Albert, Shine K. [1 ]
Golla, Murali [1 ]
Krishnan, Nithiyanandan [1 ]
Yamijala, Santosh Bhargav [2 ]
Nair, Sreeja V. [2 ]
Srinivasula, S. Murty [2 ]
Varghese, Reji [1 ]
机构：
[1] Indian Inst Sci Educ & Research Thiruvananthapura, Sch Chem, CET Campus, Trivandrum 695016, Kerala, India
[2] IISER TVM, Sch Biol, Thiruvananthapuram, Kerala, India
来源：
CHEMISTRYSELECT | 2016年 / 1卷 / 17期
关键词：
DNA nanotechnology; supramolecular chemistry; drug delivery; vesicles; fluorescence; BLOCK-COPOLYMER; SUPRAMOLECULAR ASSEMBLIES; HYBRID AMPHIPHILES; CELLULAR UPTAKE; NUCLEIC-ACIDS; DELIVERY; NANOPARTICLES; NANOMATERIALS; NONCOVALENT; MORPHOLOGY;
D O I：
10.1002/slct.201600897
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA based spherical nanostructures is one of the promising nanocarriers for drug delivery applications because of their excellent biocompatibility and unique structural features of DNA. Herein, we report the amphiphilicity driven self-assembly of DNA-phenyleneethynylene based amphiphile into luminescent vesicles and their cellular uptake toward HeLa cell. Spectroscopic and microscopic analyses reveal the self-assembly of this class of amphiphiles into vesicular nanostructures with corona made of DNA and a functional hydrophobic membrane. Vesicles exhibit promising cell permeability.
引用
收藏
页码：5389 / 5396
页数：8
相关论文
共 73 条
  • [1] Quantum Dot Lipid Oligonucleotide Bioconjugates: Toward a New Anti-MicroRNA Nanoplatform
    Aime, Ahissan
    Beztsinna, Nataliia
    Patwa, Amit
    Pokolenko, Alexander
    Bestel, Isabelle
    Barthelemy, Philippe
    [J]. BIOCONJUGATE CHEMISTRY, 2013, 24 (08) : 1345 - 1355
  • [2] Cholesterol-aided supramolecular control over chromophore packing: Twisted and coiled helices with distinct optical, chiroptical, and morphological features
    Ajayaghosh, A
    Vijayakumar, C
    Varghese, R
    George, SJ
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (03) : 456 - 460
  • [3] Albert S. K., 2014, ANGEW CHEM, V126, P8492
  • [4] Synthesis and self-assembly of DNA-chromophore hybrid amphiphiles
    Albert, Shine K.
    Golla, Murali
    Thelu, Hari Veera Prasad
    Krishnan, Nithiyanandan
    Deepak, Perapaka
    Varghese, Reji
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (29) : 6960 - 6969
  • [5] Self-Assembly of DNA-Oligo(p-phenylene-ethynylene) Hybrid Amphiphiles into Surface-Engineered Vesicles with Enhanced Emission
    Albert, Shine K.
    Thelu, Hari Veera Prasad
    Golla, Murali
    Krishnan, Nithiyanandan
    Chaudhary, Soma
    Varghese, Reji
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (32) : 8352 - 8357
  • [6] DNA block copolymer micelles - A combinatorial tool for cancer Nanotechnology
    Alemdaroglu, Fikri E.
    Alemdaroglu, N. Ceren
    Langguth, Peter
    Herrmann, Andreas
    [J]. ADVANCED MATERIALS, 2008, 20 (05) : 899 - +
  • [7] DNA-templated synthesis in three dimensions: Introducing a micellar scaffold for organic reactions
    Alemdaroglu, Fikri E.
    Ding, Ke
    Berger, Ruediger
    Herrmann, Andreas
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (25) : 4206 - 4210
  • [8] H-Aggregates of Oligophenyleneethynylene (OPE)-BODIPY Systems in Water: Guest Size-Dependent Encapsulation Mechanism and Co-aggregate Morphology
    Allampally, Naveen Kumar
    Florian, Alexander
    Mayoral, Maria Jose
    Rest, Christina
    Stepanenko, Vladimir
    Fernandez, Gustavo
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (34) : 10669 - 10678
  • [9] [Anonymous], 2014, ANGEW CHE
  • [10] Nanotubes Self-Assembled from Amphiphilic Molecules via Helical Intermediates
    Barclay, Thomas G.
    Constantopoulos, Kristina
    Matisons, Janis
    [J]. CHEMICAL REVIEWS, 2014, 114 (20) : 10217 - 10291
12345678