Biologic Therapy for Psoriatic Arthritis

被引：48

作者：

Mease, Philip J. ^{[1
,2
]}

机构：

[1] Swedish Med Ctr, Clin Rheumatol Res, Seattle, WA 98122 USA

[2] Univ Washington, Sch Med, Seattle, WA 98195 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2015年 / 41卷 / 04期

关键词：

Psoriatic arthritis; Psoriasis; Biologics; TNF inhibition; IL-12-23; inhibition; IL-17; IL-23; PLACEBO-CONTROLLED TRIAL; ANTI-INTERLEUKIN-17; MONOCLONAL-ANTIBODY; SIGNIFICANTLY IMPROVES SIGNS; DOUBLE-BLIND; ANKYLOSING-SPONDYLITIS; RHEUMATOID-ARTHRITIS; INADEQUATE RESPONSE; PLAQUE PSORIASIS; PHASE-II; EFFICACY;

D O I：

10.1016/j.rdc.2015.07.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Biologic medications, therapeutic proteins that inhibit or modulate proinflammatory immune cells and cytokines, have significantly altered clinicians' ability to effectively treat psoriatic arthritis (PsA). The first widely used biologics have been those targeting tumor necrosis factor alpha. Five agents (etanercept, infliximab, adalimumab, golimumab, and certolizumab) have shown significant benefit in all clinical domains of PsA as well as inhibiting progressive joint destruction. Treatment strategies such as treating PsA early in the disease course, treating to target and tight control, use of background methotrexate to reduce immunogenicity, and various cost-saving strategies are all being tested with biologic medicines for PsA.

引用

页码：723 / +

页数：17

共 60 条

[1] Drug Therapies for Peripheral Joint Disease in Psoriatic Arthritis: A Systematic Review [J].

Acosta Felquer, Maria Laura ;

Coates, Laura C. ;

Soriano, Enrique R. ;

Ranza, Roberto ;

Espinoza, Luis R. ;

Helliwell, Philip S. ;

FitzGerald, Oliver ;

McHugh, Neil ;

Roussou, Euthalia ;

Mease, Philip J. .

JOURNAL OF RHEUMATOLOGY, 2014, 41 (11) :2277-2285

[2]

[Anonymous], ARTHRITIS RHEUMA S10

[3] Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial [J].

Antoni, C ;

Krueger, GG ;

de Vlam, K ;

Birbara, C ;

Beutler, A ;

Guzzo, C ;

Zhou, B ;

Dooley, LT ;

Kavanaugh, A .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (08) :1150-1157

[4]

Baeten DL, 2014, ARTHRITIS RHEUMATOL, V66, pS360

[5] Infliximab plus methotrexate is superior to methotrexate alone in the treatment of psoriatic arthritis in methotrexate-naive patients: the RESPOND study [J].

Baranauskaite, Asta ;

Raffayova, Helena ;

Kungurov, N. V. ;

Kubanova, Anna ;

Venalis, Algirdas ;

Helmle, Laszlo ;

Srinivasan, Shankar ;

Nasonov, Evgeny ;

Vastesaeger, Nathan .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (04) :541-548

[6] Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features [J].

Celis, Raquel ;

Planell, Nuria ;

Fernandez-Sueiro, Jose L. ;

Sanmarti, Raimon ;

Ramirez, Julio ;

Gonzalez-Alvaro, Isidoro ;

Pablos, Jose L. ;

Canete, Juan D. .

ARTHRITIS RESEARCH & THERAPY, 2012, 14 (02)

[7] Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment [J].

Coates, L. C. ;

Fransen, J. ;

Helliwell, P. S. .

ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (01) :48-53

[8]

Coates LC, 2013, ARTHRITIS RHEUM-US, V65, pS346

[9] Efficacy of tocilizumab in a patient with refractory psoriatic arthritis [J].

Costa, Luisa ;

Caso, Francesco ;

Cantarini, Luca ;

Del Puente, Antonio ;

Scarpa, Raffaele ;

Atteno, Mariangela .

CLINICAL RHEUMATOLOGY, 2014, 33 (09) :1355-1357

[10] The role of methotrexate co-medication in TNF-inhibitor treatment in patients with psoriatic arthritis: results from 440 patients included in the NOR-DMARD study [J].

Fagerli, Karen Minde ;

Lie, Elisabeth ;

van der Heijde, Desiree ;

Heiberg, Marte Schrumpf ;

Lexberg, Ase Stavland ;

Rodevand, Eric ;

Kalstad, Synove ;

Mikkelsen, Knut ;

Kvien, Tore K. .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (01) :132-137

← 1 2 3 4 5 6 →