Immunosenescence in the nursing home elderly

被引：21
作者：
Johnstone, Jennie [1 ,6 ]
Millar, Jamie [2 ,3 ]
Lelic, Alina [2 ,3 ]
Verschoor, Chris P. [2 ,3 ]
Walter, Stephen D. [1 ]
Devereaux, Philip J. [1 ,4 ]
Bramson, Jonathan [2 ,3 ,5 ]
Loeb, Mark [1 ,3 ,4 ,5 ,6 ]
机构：
[1] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, McMaster Immunol Res Ctr, Hamilton, ON L8S 4K1, Canada
[3] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8S 4K1, Canada
[4] McMaster Univ, Dept Med, Hamilton, ON L8S 4K1, Canada
[5] McMaster Univ, Inst Infect Dis Res, Hamilton, ON L8S 4K1, Canada
[6] McMaster Univ, Hamilton, ON L8N 3Z5, Canada
来源：
BMC GERIATRICS | 2014年 / 14卷
基金：
加拿大健康研究院;
关键词：
Immunosenescence; Aging; Immune phenotypes; Nursing home elderly; SWEDISH NONA IMMUNE; T-CELL SUBSETS; PERIPHERAL-BLOOD; LYMPHOCYTE SUBPOPULATIONS; RISK PROFILE; NK CELLS; OLD-AGE; INDIVIDUALS; ASSOCIATION; POPULATION;
D O I：
10.1186/1471-2318-14-50
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: To describe T-cell and natural killer (NK) cell phenotypes within nursing home elderly. Methods: Nursing home elderly were recruited from four nursing homes in Hamilton, Ontario between September 2010 and December 2011. Healthy adults were recruited from McMaster University between September 2011 and December 2011. Nursing home elderly >= 65 years were eligible; those on immunosuppressive medications were excluded. Healthy adults >= 18-64 years were eligible. CD8+ and CD4+ T-cells% and their subsets, T-regs% and NK cell subset% were compared between the nursing home elderly and healthy adults. Results: 262 nursing home elderly were enrolled; median age 87 years and 81% were female. 16 healthy adults were enrolled; median age 31 and 50% were female. There was no significant difference between CD8+ T-cell% in nursing home and healthy adults (median 17.1 versus 18.0, p = 0.56), however there were fewer naive CD8 + T-cell% (median 0.9 versus 5.2, p < 0.001), more terminally differentiated CD8 + T-cell% (median 7.3 versus 4.1, p = 0.004) and more senescent T-cell% (median 5.3 versus 3.1, p = 0.04) in the nursing home elderly. There were more CD4+ T-cell% in the nursing home elderly compared to healthy adults (median 45.5 versus 37.1, p = 0.001). Nursing home elderly had a higher CD4+/CD8+ ratio than healthy adults (2.6 versus 1.9, p = 0.048), higher T-reg% (median 1.8 versus 0.8, p < 0.001) and increased mature NK cell% (median 12.1 versus 5.4, p = 0.001) compared to healthy adults. Conclusion: Differences in naive CD8+ T-cells, terminally differentiated and senescent CD8+ T-cells, T-regs and NK cell subsets were similar to studies involving community dwelling elderly. In contrast, the CD4+/CD8+ ratio was higher in nursing home elderly.
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页数：9
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