Poly(2-oxazoline)s as materials for biomedical applications

被引：181

作者：

de la Rosa, Victor R. ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2014年 / 25卷 / 05期

关键词：

ACCELERATED BLOOD CLEARANCE; CRITICAL SOLUTION TEMPERATURE; NONFOULING SURFACE-COATINGS; POLY(ETHYLENE GLYCOL); COMPLEMENT ACTIVATION; AQUEOUS-SOLUTIONS; GENE DELIVERY; AGGREGATION BEHAVIOR; POLYMER THERAPEUTICS; DIBLOCK COPOLYMERS;

D O I：

10.1007/s10856-013-5034-y

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The conjunction of polymers and medicine enables the development of new materials that display novel features, opening new ways to administrate drugs, design implants and biosensors, to deliver pharmaceuticals impacting cancer treatment, regenerative medicine or gene therapy. Poly(2-oxazoline)s (POx) constitute a polymer class with exceptional properties for their use in a plethora of different biomedical applications and are proposed as a versatile platform for the development of new medicine. Herein, a global vision of POx as a platform for novel biomaterials is offered, by highlighting the recent advances and breakthroughs in this fascinating field.

引用

页码：1211 / 1225

页数：15

共 161 条

[1] Poly(2-oxazolines) in biological and biomedical application contexts [J].

Adams, Nico ;

Schubert, Ulrich S. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (15) :1504-1520

[2] Facile Approach to Grafting of Poly(2-oxazoline) Brushes on Macroscopic Surfaces and Applications Thereof [J].

Agrawal, Mukesh ;

Carlos Rueda, Juan ;

Uhlmann, Petra ;

Mueller, Martin ;

Simon, Frank ;

Stamm, Manfred .

ACS APPLIED MATERIALS & INTERFACES, 2012, 4 (03) :1357-1364

[3]

[Anonymous], SUMM EUR PUBL ASS RE

[4] Polymerization of oxazolines [J].

Aoi, K ;

Okada, M .

PROGRESS IN POLYMER SCIENCE, 1996, 21 (01) :151-208

[5] Complement activation on surfaces modified with ethylene glycol units [J].

Arima, Yusuke ;

Toda, Mitsuaki ;

Iwata, Hiroo .

BIOMATERIALS, 2008, 29 (05) :551-560

[6] Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients [J].

Armstrong, Jonathan K. ;

Hempel, Georg ;

Koling, Susanne ;

Chan, Linda S. ;

Fisher, Timothy ;

Meiselman, Herbert J. ;

Garratty, George .

CANCER, 2007, 110 (01) :103-111

[7] Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure-property relationships to better defined therapeutics [J].

Barz, Matthias ;

Luxenhofer, Robert ;

Zentel, Rudolf ;

Vicent, Maria J. .

POLYMER CHEMISTRY, 2011, 2 (09) :1900-1918

[8] POLYMERIZATION OF CYCLIC IMINO ETHERS .I. OXAZOLINES [J].

BASSIRI, TG ;

LEVY, A ;

LITT, M .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER LETTERS, 1967, 5 (9PB) :871-&

[9] Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility [J].

Bauer, Marius ;

Lautenschlaeger, Christian ;

Kempe, Kristian ;

Tauhardt, Lutz ;

Schubert, Ulrich S. ;

Fischer, Dagmar .

MACROMOLECULAR BIOSCIENCE, 2012, 12 (07) :986-998

[10] A library of strictly linear poly(ethylene glycol)-poly(ethylene imine) diblock copolymers to perform structure-function relationship of non-viral gene carriers [J].

Bauhuber, Sonja ;

Liebl, Renate ;

Tomasetti, Luise ;

Rachel, Reinhard ;

Goepferich, Achim ;

Breunig, Miriam .

JOURNAL OF CONTROLLED RELEASE, 2012, 162 (02) :446-455

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