Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia

被引：16
作者：
Okuyama, Satoshi [1 ]
Fukata, Takahiro [1 ]
Nishigawa, Yuki [1 ]
Amakura, Yoshiaki [2 ]
Yoshimura, Morio [2 ]
Yoshida, Takashi [2 ]
Nakajima, Mitsunari [1 ]
Furukawa, Yoshiko [1 ]
机构：
[1] Matsuyama Univ, Coll Pharmaceut Sci, Dept Pharmaceut Pharmacol, Matsuyama, Ehime 7908578, Japan
[2] Matsuyama Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Matsuyama, Ehime 7908578, Japan
来源：
JOURNAL OF FUNCTIONAL FOODS | 2013年 / 5卷 / 04期
基金：
日本学术振兴会;
关键词：
Heptamethoxyflavone; MK-801; Schizophrenia-like behavior; Locomotion; Y-maze test; Open field test; RECEPTOR; ANTAGONIST; EXPRESSION; NOBILETIN; DEFICITS; MK-801; MEMORY;
D O I：
10.1016/j.jff.2013.07.016
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Enhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-D-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor activity are a prominent feature in the positive symptoms of schizophrenia. We showed here that the citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) has a protective effect on hyperactivity induced by MK-801 in the Y-maze test and open field test. These results suggest that HMF has the ability to relieve MK-801-induced schizophrenia positive symptom-like behavior. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2002 / 2006
页数：5
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