Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014

被引：26

作者：

Shen, Shu-Qun ^{[1
,2
]}

Wei, Hai-Xia ^{[1
,2
]}

Fu, Yong-Hang ^{[3
]}

Zhang, Hao ^{[4
]}

Mo, Qing-Yi ^{[5
]}

Wang, Xiao-Jun ^{[1
,2
]}

Deng, Sheng-Qun ^{[1
,2
]}

Zhao, Wei ^{[1
,2
]}

Liu, Yu ^{[1
,2
]}

Feng, Xiao-Shuang ^{[1
,2
]}

Chen, Wei ^{[6
]}

Peng, Hong-Juan ^{[1
,2
]}

机构：

[1] Southern Med Univ, Sch Publ Hlth & Trop Med, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Publ Hlth & Trop Med, Key Lab Prevent & Control Emerging Infect Dis, Guangdong Higher Inst, Guangzhou 510515, Guangdong, Peoples R China

[3] PLA, Hosp 458, Dept Clin Lab, Guangzhou 510602, Guangdong, Peoples R China

[4] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Guangdong, Peoples R China

[5] Southern Med Univ, Zhongshan Boai Hosp, Dept Pediat, Zhongshan 528403, Guangdong, Peoples R China

[6] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

PHYLOGENETIC ANALYSIS; GLOBAL DISTRIBUTION; AEDES-ALBOPICTUS; CHINA; URBANIZATION; TRANSMISSION; PROVINCE; FEVER; RISK;

D O I：

10.1038/srep16913

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.

引用

页数：10

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