Intramolecular cyclization reactions of aziridines with π-nucleophiles

被引：30
作者：
Bergmeier, SC [1 ]
Katz, SJ [1 ]
Huang, JF [1 ]
McPherson, H [1 ]
Donoghue, PJ [1 ]
Reed, DD [1 ]
机构：
[1] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 26期
基金：
美国国家科学基金会;
关键词：
aziridines; amines; bicyclic heterocyclic compounds;
D O I：
10.1016/j.tetlet.2004.05.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have found that aziridines will react with a variety of pi-nucleophiles in intramolecular cyclization reactions to produce nitrogen containing core structures found in a variety of bioactive molecules. These cyclizations are more general and facile than corresponding intermolecular reactions. We have examined the effects of ring size, pi-nucleophile identity and substitution on this reaction. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5011 / 5014
页数：4
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