Corosolic acid impairs human lung adenocarcinoma A549 cells proliferation by inhibiting cell migration

被引：5

作者：

Li, Biao ^{[1
]}

Li, Yongjie ^{[1
]}

Wang, Qiongyu ^{[1
]}

Li, Fan ^{[1
]}

Li, Fu ^{[1
]}

机构：

[1] Hainan Med Univ, Affiliated Hosp 2, Dept Thorac Surg, 48 Baishuitang Rd, Haikou 570311, Hainan, Peoples R China

来源：

ONCOLOGY LETTERS | 2019年 / 17卷 / 06期

关键词：

lung cancer; corosolic acid; vascular endothelial growth factor receptor 2; cytoskeleton structure; in vivo imaging system; CANCER CELLS; ACTIVATION; APOPTOSIS; VEGF; MITOCHONDRIA; RECEPTOR; BINDING; KINASE; GROWTH;

D O I：

10.3892/ol.2019.10262

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aimed to investigate the anticancer effects of corosolic acid (CA) in the human lung adenocarcinoma A549 cell line. A549 cells were treated with increasing concentrations of CA, prior to assessing cell viability, migration rate, vascular endothelial growth factor receptor 2 (VEGFR2) kinase activity and cytoskeleton structure. In addition, in vivo imaging system was used to analyze the anticancer effects of CA in vivo. Results demonstrated that CA exhibited a low cytotoxicity with a half maximal inhibitory concentration of 65 mu M. In addition, 4 mu M CA efficiently inhibited A549 cell migration. Furthermore, CA inhibited VEGFR2 kinase activity and disrupted tubulin structure. Data also revealed that CA inhibited A549 cell proliferation in a xenograft mouse model. In conclusion, results from the present study suggested that CA may be used as a novel potential therapy for lung cancer.

引用

页码：5747 / 5753

页数：7

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