Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor

被引：27

作者：

Zhu, Jing Xuan ^{[1
]}

Ding, Lijian ^{[1
,2
]}

He, Shan ^{[1
,2
]}

机构：

[1] Ningbo Univ, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biophar, Ningbo, Zhejiang, Peoples R China

[2] Ningbo Univ, Key Lab Marine Biotechnol Zhejiang Prov, Ningbo, Zhejiang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Marine-derived fungi; Aspergillus versicolor; epigenetic manipulation; antibacterial activity; NATURAL-PRODUCTS; ACID;

D O I：

10.1080/14786419.2018.1465423

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 mu g/mL. [GRAPHICS] .

引用

页码：1191 / 1195

页数：5

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