Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

被引：203

作者：

Sedighi, Mansour ^{[1
]}

Bialvaei, Abed Zahedi ^{[1
]}

Hamblin, Michael R. ^{[2
,3
,4
]}

Ohadi, Elnaz ^{[1
]}

Asadi, Arezoo ^{[1
]}

Halajzadeh, Masoumeh ^{[1
]}

Lohrasbi, Vahid ^{[1
]}

Mohammadzadeh, Nima ^{[1
]}

Amiriani, Taghi ^{[5
]}

Krutova, Marcela ^{[6
,7
]}

Amini, Abolfazl ^{[8
]}

Kouhsari, Ebrahim ^{[1
,8
]}

机构：

[1] Iran Univ Med Sci, Sch Med, Dept Microbiol, Tehran, Iran

[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[3] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA

[4] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USA

[5] Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Golestan, Iran

[6] Charles Univ Prague, Dept Med Microbiol, Fac Med 2, Prague, Czech Republic

[7] Motol Univ Hosp, Prague, Czech Republic

[8] Golestan Univ Med Sci, Lab Sci Res Ctr, Gorgan, Golestan, Iran

来源：

CANCER MEDICINE | 2019年 / 8卷 / 06期

关键词：

bacteriotherapy; cancer; chemotherapy; immunotherapy; radiotherapy; tumoricidal agents; TUMOR-TARGETING SALMONELLA; GENETICALLY-ENGINEERED SALMONELLA; CHEMOTHERAPY-INDUCED DIARRHEA; RADIATION-INDUCED DIARRHEA; COLORECTAL-CANCER; CYTOSINE DEAMINASE; GENE-THERAPY; CLOSTRIDIUM-ONCOLYTICUM; PROTEIN DELIVERY; RADIO-FREQUENCY;

D O I：

10.1002/cam4.2148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria-assisted tumor-targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy.

引用

页码：3167 / 3181

页数：15

共 162 条

[1] The potential use of biogas producing microorganisms in radiation protection [J].