CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis

被引：11

作者：

Dursi, L. Jonathan ^{[1
]}

Bozoky, Zoltan ^{[2
]}

de Borja, Richard ^{[3
,13
]}

Li, Haoyuan ^{[4
]}

Bujold, David ^{[5
]}

Lipski, Adam ^{[4
,6
]}

Rashid, Shaikh Farhan ^{[1
]}

Sethi, Amanjeev ^{[1
]}

Memon, Neelam ^{[4
]}

Naidoo, Dashaylan ^{[4
,24
]}

Coral-Sasso, Felipe ^{[4
]}

Wong, Matthew ^{[7
]}

Quirion, P-O ^{[5
]}

Lu, Zhibin ^{[8
]}

Agarwal, Samarth ^{[9
]}

Pavlov, Yuriy ^{[1
]}

Ponomarev, Andrew ^{[4
,10
]}

Husic, Mia ^{[11
]}

Pace, Krista ^{[1
]}

Palmer, Samantha ^{[1
]}

Grover, Stephanie A. ^{[12
]}

Hakgor, Sevan ^{[13
]}

Siu, Lillian L. ^{[13
]}

Malkin, David ^{[14
]}

Virtanen, Carl

Pugh, Trevor J. ^{[3
,13
,15
]}

Jacques, Pierre-Etienne ^{[16
]}

Joly, Yann ^{[17
,18
]}

Jones, Steven J. M. ^{[4
,19
]}

Bourque, Guillaume ^{[18
,20
,21
]}

Brudno, Michael ^{[1
,22
,23
]}

机构：

[1] Univ Hlth Network, DATA Team, Toronto, ON M5G 2C4, Canada

[2] Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada

[3] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

[4] BC Canc Res Inst, Canadas Michael Smith Genome Sci Ctr, Prov Hlth Serv Author, Vancouver, BC V5Z 4S6, Canada

[5] Canadian Ctr Computat Genom, Montreal, PQ H3A 0G1, Canada

[6] Zymeworks, Vancouver, BC V6H 3V9, Canada

[7] Univ Waterloo, Waterloo, ON N2L 3G1, Canada

[8] Univ Hlth Network, Toronto, ON M5G 2C4, Canada

[9] Univ Toronto, Toronto, ON M5T 3A1, Canada

[10] GenX, Nottingham NG1 1GF, England

[11] Hosp Sick Children, Ctr Computat Med, Toronto, ON M5G 1X8, Canada

[12] Univ Toronto, Hosp Sick Children, Genet & Genome Biol Program, Toronto, ON M5G 1X8, Canada

[13] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

[14] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[15] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada

[16] Univ Sherbrooke, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

[17] McGill Univ, Ctr Genom & Policy, Dept Human Genet, Montreal, PQ H3A 0C7, Canada

[18] McGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada

[19] Univ British Columbia, Dept Med Genet, Columbia, BC V6H 3N1, Canada

[20] McGill Univ, Canadian Ctr Computat Genom C3G, Montreal, PQ H3A 0G1, Canada

[21] McGill Univ, Fac Med, McGill Genome Ctr, Montreal, PQ H3A 0G1, Canada

[22] Univ Toronto, Dept Comp Sci, Toronto, ON M5T 3A1, Canada

[23] Vector Inst, Toronto, ON M5G 1M1, Canada

[24] Providence Hlth & Serv, Mol Genom Lab, Portland, OR USA

来源：

CELL GENOMICS | 2021年 / 1卷 / 02期

基金：

加拿大创新基金会;

关键词：

D O I：

10.1016/j.xgen.2021.100033

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Alliance for Genomics and Health (GA4GH) and currently hosts data for five pan-Canadian projects. We describe CanDIG's key design decisions and features as a guide for other federated data systems.

引用

页数：7

共 50 条

[31] Multi-omic measurements of heterogeneity in HeLa cells across laboratories
Yansheng Liu
Yang Mi
Torsten Mueller
Saskia Kreibich
Evan G. Williams
Audrey Van Drogen
Christelle Borel
Max Frank
Pierre-Luc Germain
Isabell Bludau
Martin Mehnert
Michael Seifert
Mario Emmenlauer
Isabel Sorg
Fedor Bezrukov
Frederique Sloan Bena
Hu Zhou
Christoph Dehio
Giuseppe Testa
Julio Saez-Rodriguez
Stylianos E. Antonarakis
Wolf-Dietrich Hardt
Ruedi Aebersold
Nature Biotechnology, 2019, 37 : 314 - 322
[32] Multi-omic analyses and network biology in cardiovascular disease
Reitz, Cristine J.
Kuzmanov, Uros
Gramolini, Anthony O.
PROTEOMICS, 2023, 23 (21-22)
[33] Multi-omic measurements of heterogeneity in HeLa cells across laboratories
Liu, Yansheng
Mi, Yang
Mueller, Torsten
Kreibich, Saskia
Williams, Evan G.
Van Drogen, Audrey
Borel, Christelle
Franks, Max
Germain, Pierre-Luc
Bludau, Isabell
Mehnert, Martin
Seifert, Michael
Emmenlauer, Mario
Sorg, Isabel
Bezrukov, Fedor
Bena, Frederique Sloan
Zhou, Hu
Dehio, Christoph
Testa, Giuseppe
Saez-Rodriguez, Julio
Antonarakis, Stylianos E.
Hardt, Wolf-Dietrich
Aebersold, Ruedi
NATURE BIOTECHNOLOGY, 2019, 37 (03) : 314 - +
[34] Advancing discovery in hearing research via biologist-friendly access to multi-omic data
Ronna Hertzano
Anup Mahurkar
Human Genetics, 2022, 141 : 319 - 322
[35] Advancing discovery in hearing research via biologist-friendly access to multi-omic data
Hertzano, Ronna
Mahurkar, Anup
HUMAN GENETICS, 2022, 141 (3-4) : 319 - 322
[36] Methods for multi-omic data integration in cancer research
Hernandez-Lemus, Enrique
Ochoa, Soledad
FRONTIERS IN GENETICS, 2024, 15
[37] A Comprehensive Analysis of Cutaneous Melanoma Patients in Greece Based on Multi-Omic Data
Kontogianni, Georgia
Voutetakis, Konstantinos
Piroti, Georgia
Kypreou, Katerina
Stefanaki, Irene
Vlachavas, Efstathios Iason
Pilalis, Eleftherios
Stratigos, Alexander
Chatziioannou, Aristotelis
Papadodima, Olga
CANCERS, 2023, 15 (03)
[38] The Human Tumor Atlas Network's beginning steps toward the future of collaborative multi-omic discovery
Page, David B.
CELL REPORTS MEDICINE, 2022, 3 (02)
[39] A guided network estimation approach using multi-omic information
Bartzis, Georgios
Peeters, Carel F. W.
Ligterink, Wilco
Van Eeuwijk, Fred A.
BMC BIOINFORMATICS, 2024, 25 (01):
[40] The mitochondrial multi-omic response to exercise training across rat tissues
Amar, David
Gay, Nicole R.
Jimenez-Morales, David
Beltran, Pierre M. Jean
Ramaker, Megan E.
Raja, Archana Natarajan
Zhao, Bingqing
Sun, Yifei
Marwaha, Shruti
Gaul, David A.
Hershman, Steven G.
Ferrasse, Alexis
Xia, Ashley
Lanza, Ian
Fernandez, Facundo M.
Montgomery, Stephen B.
Hevener, Andrea L.
Ashley, Euan A.
Walsh, Martin J.
Sparks, Lauren M.
Burant, Charles F.
Rector, R. Scott
Thyfault, John
Wheeler, Matthew T.
Goodpaster, Bret H.
Coen, Paul M.
Schenk, Simon
Bodine, Sue C.
Lindholm, Malene E.
CELL METABOLISM, 2024, 36 (06) : 1411 - 1429.e10

← 1 2 3 4 5 →