The current status of targeting BAFF/BLyS for autoimmune diseases

被引：36

作者：

Ramanujam, M

Davidson, A ^{[1
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 05期

关键词：

autoimmune diseases; B cells; BAFF (BLyS); co-stimulation; therapy;

D O I：

10.1186/ar1222

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is increasingly recognized that B cells have multiple functions that contribute to the pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate therapeutic intervention. The tumor necrosis factor-like molecule BAFF (BLyS) is a key B cell survival factor and its receptors are expressed on most peripheral B cells. Several different BAFF antagonists are under development and in early clinical trials. We review here the rationale for BAFF blockade, and its predicted mechanism of action in autoimmune diseases.

引用

页码：197 / 202

页数：6

共 47 条

[1] BAFF selectively enhances the survival of plasmablasts generated from human memory B cells [J].

Avery, DT ;

Kalled, SL ;

Ellyard, JI ;

Ambrose, C ;

Bixler, SA ;

Thien, M ;

Brink, R ;

Mackay, F ;

Hodgkin, PD ;

Tangye, SG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (02) :286-297

[2] Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator [J].

Baker, KP ;

Edwards, BM ;

Main, SH ;

Choi, GH ;

Wager, RE ;

Halpern, WG ;

Lappin, PB ;

Riccobene, T ;

Abramian, D ;

Sekut, L ;

Sturm, B ;

Poortman, C ;

Minter, RR ;

Dobson, CL ;

Williams, E ;

Carmen, S ;

Smith, R ;

Roschke, V ;

Hilbert, DM ;

Vaughan, TJ ;

Albert, VR .

ARTHRITIS AND RHEUMATISM, 2003, 48 (11) :3253-3265

[3] Blood dendritic cells interact with splenic marginal zone B cells to initiate T-Independent immune responses [J].

Balázs, M ;

Martin, F ;

Zhou, T ;

Kearney, JF .

IMMUNITY, 2002, 17 (03) :341-352

[4] Peripheral B-cell maturation: the intersection of selection and homeostasis [J].

Cancro, MP .

IMMUNOLOGICAL REVIEWS, 2004, 197 :89-101

[5]

Cassese G, 2001, EUR J IMMUNOL, V31, P2726, DOI 10.1002/1521-4141(200109)31:9<2726::AID-IMMU2726>3.0.CO

[6]

2-H

[7]

Cheema GS, 2001, ARTHRITIS RHEUM-US, V44, P1313, DOI 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO

[8]

2-S

[9] Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response [J].

Do, RKG ;

Hatada, E ;

Lee, H ;

Tourigny, MR ;

Hilbert, D ;

Chen-Kiang, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) :953-964

[10]

Furie R, 2003, ARTHRITIS RHEUM, V48, pS377

← 1 2 3 4 5 →