Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

被引：25

作者：

Aktas, Zeynep ^{[1
]}

Cansu, Ali ^{[2
]}

Erdogan, Deniz ^{[3
]}

Take, Guelnur ^{[3
]}

Goktas, Guleser ^{[3
]}

Ozdek, Sengul ^{[1
]}

Serdaroglu, Ayse ^{[4
]}

机构：

[1] Gazi Univ, Sch Med, Dept Ophthalmol, Ankara, Turkey

[2] Karadeniz Tech Univ, Sch Med, Dept Pediat Neurol, Trabzon, Turkey

[3] Gazi Univ, Sch Med, Dept Histol & Embryol, Ankara, Turkey

[4] Gazi Univ, Sch Med, Dept Pediat Neurol, Ankara, Turkey

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2009年 / 18卷 / 06期

关键词：

Oxcarbazepine; Valproic acid; Retinal ganglion cell; COLOR-VISION; ANTIEPILEPTIC DRUGS; ADOLESCENTS;

D O I：

10.1016/j.seizure.2009.02.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number. (C) 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：396 / 399

页数：4

共 21 条

[1] Oxcarbazepine: A review of its use in children with epilepsy [J].