Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.:: Isolation, structure elucidation, and structure-activity relationship

被引：85

作者：

Uddin, Jasim

Ueda, Katsuhiro ^{[1
]}

Siwu, Eric R. O.

Kita, Masaki

Uemura, Daisuke

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Nishihara, Okinawa 9030213, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[3] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[4] Nagoya Univ, Inst Adv Res, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 20期

关键词：

diterpene; labdane alkaloid; haterumaimide; cytotoxicity; structure-activity relationship;

D O I：

10.1016/j.bmc.2006.06.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four labdane alkaloids, haterumaimides N-Q (1-4), were isolated from an ascidian Lissoclinum sp. and their structures were elucidated by chemical and spectral analyses. Investigation of the structure-activity relationships of haterumaimides J-K, N-Q, and 14 related compounds suggested that the presence of hydroxyl groups at C-6, C-7, C-12, and C-18, a chlorine atom at C-2, and an imido NH in ring C should be essential for cytotoxicity against P388 cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6954 / 6961

页数：8

共 21 条

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