Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans

被引：12

作者：

Adiels, Martin ^{[1
,2
]}

Mardinoglu, Adil ^{[3
,4
]}

Taskinen, Marja-Riitta ^{[5
,6
]}

Boren, Jan ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Hlth Matr Unit, Gothenburg, Sweden

[3] Chalmers Univ Technol, Dept Biol & Biol Engn, S-41296 Gothenburg, Sweden

[4] KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden

[5] Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland

[6] Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland

来源：

FRONTIERS IN PHYSIOLOGY | 2015年 / 6卷

基金：

英国医学研究理事会;

关键词：

very low density lipoproteins; apoB; multocomnpartmental modeling; kinetics; stable isotopes; LOW-DENSITY LIPOPROTEINS; FATTY LIVER-DISEASE; A-I KINETICS; HEPARAN-SULFATE PROTEOGLYCANS; TYPE-2 DIABETIC MEN; APOLIPOPROTEIN B-100; NONALCOHOLIC STEATOHEPATITIS; MULTICOMPARTMENTAL MODEL; POSTPRANDIAL STATE; INSULIN-RESISTANCE;

D O I：

10.3389/fphys.2015.00342

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

引用

页数：8

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