Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach

被引：226
作者：
Regoli, F
Gorbi, S
Frenzilli, G
Nigro, M
Corsi, I
Focardi, S
Winston, GW
机构：
[1] Univ Ancona, Ist Biol & Genet, I-60100 Ancona, Italy
[2] Univ Pisa, Dipartimento Morfol Umana & Biol Applicata, I-56100 Pisa, Italy
[3] Univ Siena, Dipartimento Sci Ambientali, I-53100 Siena, Italy
[4] Minist Hlth, Dept Environm Hlth, Jerusalem, Israel
来源：
MARINE ENVIRONMENTAL RESEARCH | 2002年 / 54卷 / 3-5期
关键词：
biomarkers; oxidative stress; oxyradicals; antioxidants; total oxyradical scavenging capacity (TOSC);
D O I：
10.1016/S0141-1136(02)00146-0
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
An integrate approach will be discussed for investigations on oxidative stress in xenobiotic toxicity. While the analysis of individual antioxidants is useful for their sensitivity and to understand the mode of action of a stressor, the integration with the analysis of the total antioxidant capacity provides a more holistic assessment of the overall biological significance of such variations. TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：419 / 423
页数：5
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