Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation

被引：119

作者：

Mottaghy, FM ^{[1
]}

Krause, BJ

Kemna, LJ

Töpper, R

Tellmann, L

Beu, M

Pascual-Leone, A

Müller-Gärtner, HW

机构：

[1] Res Ctr Julich, Dept Nucl Med, KME, D-52426 Julich, Germany

[2] Univ Dusseldorf, Dept Nucl Med, D-40225 Dusseldorf, Germany

[3] Res Ctr Julich, Inst Med, IME, D-52426 Julich, Germany

[4] Rhein Westfal TH Aachen, Dept Neurol, D-52057 Aachen, Germany

[5] Beth Israel Deaconess Med Ctr, Dept Neurol, Lab Magnet Brain Stimulat, Boston, MA 02215 USA

[6] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 280卷 / 03期

关键词：

repetitive transcranial magnetic stimulation; verbal working memory; positron emission tomography; functional lesion; dorsolateral prefrontal cortex; regional cerebral blood flow;

D O I：

10.1016/S0304-3940(00)00798-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of repetitive transcranial magnetic stimulation (rTMS) on changes in regional cerebral blood flow (rCBF) as revealed by positron emission tomography (PET) while subjects performed a 2-back verbal working memory (WM) task. rTMS to the right or left dorsolateral prefrontal cortex (DLPFC), but not to the midline frontal cortex, significantly worsened performance in the WM task while inducing significant reductions in rCBF at the stimulation site and in distant brain regions. These results for the first time demonstrate the ability of rTMS to produce temporary functional lesions in elements of a neuronal network thus changing its distributed activations and resulting in behavioral consequences. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：167 / 170

页数：4

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