Nine new ent-labdane diterpenoids from the aerial parts of Andrographis paniculata

被引：38

作者：

Chen, Li-Xia

Qiu, Feng

Wei, Hong

Qu, Ge-Xia

Yao, Xin-Sheng

机构：

[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[2] Guangxi Inst Tradit Chinese Med & Pharmaceut Sci, Nanning, Guangxi Prov, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2006年 / 89卷 / 11期

关键词：

D O I：

10.1002/hlca.200690237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nine new ent-labdane-type diterpenoids (1-9), mostly in the form of the corresponding 16,15-lactones, were isolated from the 85%-EtOH extract of the aerial parts of Andrographis paniculata NEES., together with nine known compounds (10-18). Their structures were deduced by in-depth NMR spectroscopy and high-resolution mass spectrometry.

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页码：2654 / 2664

页数：11

相关论文

共 21 条

[1] Microbial hydroxylation/functionalization of terpenoid synthons derived from communic acids [J].

Aranda, G ;

Azerad, R ;

Maurs, M ;

Bertho, G ;

Jiménez-González, D ;

Cabrera-Torres, E ;

Barrero, AF .

PHYTOCHEMISTRY, 2000, 54 (01) :23-27

[2] MINOR DITERPENOID CONSTITUENTS OF ANDROGRAPHIS-PANICULATA NEES [J].

BALMAIN, A ;

CONNOLLY, JD .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (12) :1247-1251

[3] ANDROGRAPHOLIDE - FURTHER TRANSFORMATIONS AND STEREOCHEMICAL EVIDENCE STRUCTURE OF ISOANDROGRAPHOLIDE [J].

CAVA, MP ;

CHAN, WR ;

STEIN, RP ;

WILLIS, CR .

TETRAHEDRON, 1965, 21 (09) :2617-&

[4] STRUCTURE AND STEREOCHEMISTRY OF NEOANDROGRAPHOLIDE, A DITERPENE GLUCOSIDE FROM ANDROGRAPHIS-PANICULATA NEES [J].

CHAN, WR ;

TAYLOR, DR ;

WILLIS, CR ;

BODDEN, RL ;

FEHLHABER, HW .

TETRAHEDRON, 1971, 27 (21) :5081-+

[5]

Chang HM, 1987, PHARM APPL CHINESE M, V2, P918

[6] Isolation and identification of seven glucuronide conjugates of andrographolide in human urine [J].

Cui, L ;

Qiu, F ;

Yao, XS .

DRUG METABOLISM AND DISPOSITION, 2005, 33 (04) :555-562

[7]

FUJITA T, 1984, CHEM PHARM BULL, V32, P2117

[8]

GEORGE MARIAM, 1949, Indian Journal of Medical Research, V37, P169

[9] In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: A structure-activity study [J].

Han, BH ;

Yang, HO ;

Kang, YH ;

Suh, DY ;

Go, HJ ;

Song, WJ ;

Kim, YC ;

Park, MK .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (14) :2626-2630

[10]

Haynes LJ, 1955, MOD METHOD PLANT, V2, P583