Nine new ent-labdane diterpenoids from the aerial parts of Andrographis paniculata

被引:38
作者
Chen, Li-Xia
Qiu, Feng
Wei, Hong
Qu, Ge-Xia
Yao, Xin-Sheng
机构
[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
[2] Guangxi Inst Tradit Chinese Med & Pharmaceut Sci, Nanning, Guangxi Prov, Peoples R China
关键词
D O I
10.1002/hlca.200690237
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nine new ent-labdane-type diterpenoids (1-9), mostly in the form of the corresponding 16,15-lactones, were isolated from the 85%-EtOH extract of the aerial parts of Andrographis paniculata NEES., together with nine known compounds (10-18). Their structures were deduced by in-depth NMR spectroscopy and high-resolution mass spectrometry.
引用
收藏
页码:2654 / 2664
页数:11
相关论文
共 21 条
  • [1] Microbial hydroxylation/functionalization of terpenoid synthons derived from communic acids
    Aranda, G
    Azerad, R
    Maurs, M
    Bertho, G
    Jiménez-González, D
    Cabrera-Torres, E
    Barrero, AF
    [J]. PHYTOCHEMISTRY, 2000, 54 (01) : 23 - 27
  • [2] MINOR DITERPENOID CONSTITUENTS OF ANDROGRAPHIS-PANICULATA NEES
    BALMAIN, A
    CONNOLLY, JD
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (12): : 1247 - 1251
  • [3] ANDROGRAPHOLIDE - FURTHER TRANSFORMATIONS AND STEREOCHEMICAL EVIDENCE STRUCTURE OF ISOANDROGRAPHOLIDE
    CAVA, MP
    CHAN, WR
    STEIN, RP
    WILLIS, CR
    [J]. TETRAHEDRON, 1965, 21 (09) : 2617 - &
  • [4] STRUCTURE AND STEREOCHEMISTRY OF NEOANDROGRAPHOLIDE, A DITERPENE GLUCOSIDE FROM ANDROGRAPHIS-PANICULATA NEES
    CHAN, WR
    TAYLOR, DR
    WILLIS, CR
    BODDEN, RL
    FEHLHABER, HW
    [J]. TETRAHEDRON, 1971, 27 (21) : 5081 - +
  • [5] Chang HM, 1987, PHARM APPL CHINESE M, V2, P918
  • [6] Isolation and identification of seven glucuronide conjugates of andrographolide in human urine
    Cui, L
    Qiu, F
    Yao, XS
    [J]. DRUG METABOLISM AND DISPOSITION, 2005, 33 (04) : 555 - 562
  • [7] FUJITA T, 1984, CHEM PHARM BULL, V32, P2117
  • [8] GEORGE MARIAM, 1949, Indian Journal of Medical Research, V37, P169
  • [9] In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: A structure-activity study
    Han, BH
    Yang, HO
    Kang, YH
    Suh, DY
    Go, HJ
    Song, WJ
    Kim, YC
    Park, MK
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (14) : 2626 - 2630
  • [10] Haynes LJ, 1955, MOD METHOD PLANT, V2, P583