Using Molecular Biology to Maximize Concurrent Training

被引:45
作者
Baar, Keith [1 ]
机构
[1] Univ Calif Davis, Funct Mol Biol Lab, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA
关键词
HUMAN SKELETAL-MUSCLE; UNFOLDED PROTEIN RESPONSE; RESISTANCE EXERCISE; MITOCHONDRIAL BIOGENESIS; ENDURANCE EXERCISE; RAG GTPASES; AMINO-ACIDS; METABOLIC ADAPTATION; INDUCED HYPERTROPHY; ADAPTIVE RESPONSES;
D O I
10.1007/s40279-014-0252-0
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Very few sports use only endurance or strength. Outside of running long distances on a flat surface and power-lifting, practically all sports require some combination of endurance and strength. Endurance and strength can be developed simultaneously to some degree. However, the development of a high level of endurance seems to prohibit the development or maintenance of muscle mass and strength. This interaction between endurance and strength is called the concurrent training effect. This review specifically defines the concurrent training effect, discusses the potential molecular mechanisms underlying this effect, and proposes strategies to maximize strength and endurance in the high-level athlete.
引用
收藏
页码:S117 / S125
页数:9
相关论文
共 68 条
[11]   The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle [J].
Chinsomboon, Jessica ;
Ruas, Jorge ;
Gupta, Rana K. ;
Thom, Robyn ;
Shoag, Jonathan ;
Rowe, Glenn C. ;
Sawada, Naoki ;
Raghuram, Srilatha ;
Arany, Zoltan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (50) :21401-21406
[12]   Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men [J].
Churchward-Venne, Tyler A. ;
Burd, Nicholas A. ;
Mitchell, Cameron J. ;
West, Daniel W. D. ;
Philp, Andrew ;
Marcotte, George R. ;
Baker, Steven K. ;
Baar, Keith ;
Phillips, Stuart M. .
JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (11) :2751-2765
[13]   Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle [J].
Coffey, Vernon G. ;
Jemiolo, Bozena ;
Edge, Johann ;
Garnham, Andrew P. ;
Trappe, Scott W. ;
Hawley, John A. .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2009, 297 (05) :R1441-R1451
[14]   Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle [J].
Coffey, Vernon G. ;
Pilegaard, Henriette ;
Garnham, Andrew P. ;
O'Brien, Brendan J. ;
Hawley, John A. .
JOURNAL OF APPLIED PHYSIOLOGY, 2009, 106 (04) :1187-1197
[15]   Oral leucine administration stimulates protein synthesis in rat skeletal muscle [J].
Crozier, SJ ;
Kimball, SR ;
Emmert, SW ;
Anthony, JC ;
Jefferson, LS .
JOURNAL OF NUTRITION, 2005, 135 (03) :376-382
[16]   Endurance training in mice increases the unfolded protein response induced by a high-fat diet [J].
Deldicque, Louise ;
Cani, Patrice D. ;
Delzenne, Nathalie M. ;
Baar, Keith ;
Francaux, Marc .
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2013, 69 (02) :215-225
[17]   ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1 [J].
Deldicque, Louise ;
Bertrand, Luc ;
Patton, Amy ;
Francaux, Marc ;
Baar, Keith .
PLOS ONE, 2011, 6 (06)
[18]   The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis [J].
Deldicque, Louise ;
Cani, Patrice D. ;
Philp, Andrew ;
Raymackers, Jean-Marc ;
Meakin, Paul J. ;
Ashford, Michael L. J. ;
Delzenne, Nathalie M. ;
Francaux, Marc ;
Baar, Keith .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2010, 299 (05) :E695-E705
[19]   Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise [J].
Drummond, Micah J. ;
Fry, Christopher S. ;
Glynn, Erin L. ;
Timmerman, Kyle L. ;
Dickinson, Jared M. ;
Walker, Dillon K. ;
Gundermann, David M. ;
Volpi, Elena ;
Rasmussen, Blake B. .
JOURNAL OF APPLIED PHYSIOLOGY, 2011, 111 (01) :135-142
[20]   Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis [J].
Drummond, Micah J. ;
Fry, Christopher S. ;
Glynn, Erin L. ;
Dreyer, Hans C. ;
Dhanani, Shaheen ;
Timmerman, Kyle L. ;
Volpi, Elena ;
Rasmussen, Blake B. .
JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (07) :1535-1546