Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report

被引：11

作者：

Woo, Hyun Sun ^{[1
]}

Lee, Kyoung Hwa ^{[1
]}

Yoon, Phill Hoon ^{[1
]}

Kim, Su Ji ^{[1
]}

Park, Inkeun ^{[1
]}

Kim, Young Saing ^{[1
]}

Ahn, Hee Kyung ^{[1
]}

Hong, Junshik ^{[1
]}

Shin, Dong Bok ^{[1
]}

Sym, Sun Jin ^{[1
]}

机构：

[1] Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Hematol & Oncol, Inchon 21565, South Korea

来源：

CANCER RESEARCH AND TREATMENT | 2015年 / 47卷 / 04期

关键词：

Oxaliplatin; Colorectal neoplasms; Thrombocytopenia; Neutropenia; ADVANCED COLORECTAL-CANCER; OF-THE-LITERATURE; PANCYTOPENIA; FLUOROURACIL; LEUCOVORIN; TRIAL;

D O I：

10.4143/crt.2014.052

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.

引用

收藏

页码：949 / 953

页数：5

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