Mobility, mood and site of care impact health related quality of life in Parkinson's disease

被引：11

作者：

Nutt, J. G. ^{[1
]}

Siderowf, A. D. ^{[2
]}

Guttman, M. ^{[3
]}

Schmidt, P. N. ^{[4
]}

Zamudio, J. I. ^{[4
]}

Wu, S. S. ^{[5
]}

Okun, M. S. ^{[4
]}

Simuni, T. ^{[6
]}

Parashos, F. S. A. ^{[7
]}

Dahodwala, N. A. ^{[2
]}

Davis, T. L. ^{[8
]}

Giladi, N. ^{[9
]}

Gurevich, T. ^{[9
]}

Hauser, R. A. ^{[10
]}

Jankovic, J. ^{[11
]}

Lyons, K. E. ^{[12
]}

Marsh, L. ^{[13
]}

Miyasaki, J. M.

Morgan, J. C. ^{[14
]}

Santiago, A. J. ^{[15
,16
]}

Tarsy, D. ^{[17
]}

Mari, Z. ^{[18
]}

Malaty, I. A. ^{[5
]}

Nelson, E. C. ^{[19
]}

机构：

[1] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[2] Univ Penn, Philadelphia, PA 19104 USA

[3] Univ Toronto, Toronto, ON M5S 1A1, Canada

[4] Natl Parkinson Fdn, Miami, FL USA

[5] Univ Florida, Gainesville, FL 32611 USA

[6] Northwestern Univ, Evanston, IL 60208 USA

[7] Struthers Parkinson Ctr, Golden Valley, MN USA

[8] Vanderbilt Univ, Nashville, TN USA

[9] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel

[10] Univ S Florida, Tampa, FL 33620 USA

[11] Baylor Coll Med, Houston, TX 77030 USA

[12] Univ Kansas, Lawrence, KS 66045 USA

[13] DeBakey Vet Affairs Med Ctr, Houston, TX USA

[14] Georgia Regents Univ, Augusta, GA USA

[15] Muhammad Ali Parkinson Ctr, Phoenix, AZ USA

[16] Barrow Neurol Inst, Phoenix, AZ USA

[17] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA

[18] Johns Hopkins Med Ctr, Baltimore, MD USA

[19] Dartmouth Hitchcock Med Ctr, Lebanon, NH USA

来源：

PARKINSONISM & RELATED DISORDERS | 2014年 / 20卷 / 03期

关键词：

Parkinson's disease; Health related quality of life; Best practices; Quality improvement; CONTROLLED-TRIAL; MORTALITY; QUESTIONNAIRE; DEPRESSION; DISABILITY; SYMPTOMS; NONMOTOR; CRITERIA;

D O I：

10.1016/j.parkreldis.2013.10.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Examine the correlates of Health Related Quality of Life (HRQL) in a large cohort of Parkinson's disease (PD) patients from National Parkinson Foundation (NPF) Centers of Excellence (COEs). Background: Improving outcomes for PD will depend upon uncovering disease features impacting HRQL to identify targets for intervention and variables for risk-adjustment models. Differences in HRQL outcomes between COEs could uncover modifiable aspects of care delivery. Methods: This cross-sectional study examined the relative contribution of demographic, social, clinical and treatment features potentially related to HRQL, as measured by the PDQ-39, in 4601 consecutive subjects from 18 COEs. Stepwise linear regression was utilized to identify correlates of HRQL. Results: The variability in the PDQ-39 summary index score correlated with MY stage (R-2 = 22%), Timed up and Go (TUG) (17%), disease duration (11%), comorbidities (8%), cognitive status (8%), antidepressant use (6%) and center at which a patient received care (5%). Stepwise regression reordered the importance of the variables, with the H&Y first and TUG and the center becoming equal and the second most important variables determining the PDQ-39 total score. All independent variables together accounted for 44% of the variability in HRQL. Conclusions: We confirmed many but not all HRQL associations found in smaller studies. A novel observation was that the site of care was an important contributor to HRQL, suggesting that comparison of outcomes and processes among centers may identify best practices. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：274 / 279

页数：6

共 29 条

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[Anonymous], MOV DISORD

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