A protective function for interleukin 17A in T cell-mediated intestinal inflammation

被引：642

作者：

O'Connor, William, Jr. ^{[1
]}

Kamanaka, Masahito ^{[1
]}

Booth, Carmen J. ^{[2
]}

Town, Terrence ^{[1
]}

Nakae, Susumu ^{[3
]}

Iwakura, Yoichiro ^{[3
]}

Kolls, Jay K. ^{[4
]}

Flavell, Richard A. ^{[1
,5
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Comparat Med Sect, New Haven, CT 06510 USA

[3] Univ Tokyo, Ctr Med Expt, Tokyo, Japan

[4] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[5] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 06期

关键词：

BOWEL-DISEASE; AUTOIMMUNE INFLAMMATION; NEUTROPHIL RECRUITMENT; INTERFERON-GAMMA; IL-23; MICE; EXPRESSION; DISTINCT; IL-17; RESPONSES;

D O I：

10.1038/ni.1736

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL-23 is emerging, the function of IL-17 in inflammatory bowel disease remains unclear. Here we demonstrate IL-17A-mediated protection in the CD45RB(hi) transfer model of colitis. An accelerated wasting disease elicited by T cells deficient in IL-17A correlated with higher expression of genes encoding T helper type 1-type cytokines in colon tissue. IL-17A also modulated T helper type 1 polarization in vitro. Furthermore, T cells deficient in the IL-17 receptor elicited an accelerated, aggressive wasting disease relative to that elicited by wild-type T cells in recipient mice. Our data demonstrate a protective function for IL-17 and identify T cells as not only the source but also a target of IL-17 in vivo.

引用

页码：603 / U65

页数：8

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