Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China

被引：90

作者：

Xin, Deli ^{[1
]}

Mi, Zuhuang ^{[2
]}

Han, Xu ^{[3
]}

Qin, Ling ^{[2
]}

Li, Jing ^{[1
]}

Wei, Tianli ^{[1
]}

Chen, Xiaogeng ^{[1
]}

Ma, Shaojie ^{[1
]}

Hou, Ancun ^{[1
]}

Li, Gui ^{[1
]}

Shi, Dawei ^{[1
]}

机构：

[1] Capital Med Univ, Dept Pediat, Beijing Friendship Hosp, Beijing 100050, Peoples R China

[2] Wuxi Res Inst Genet & Cloning Technol, Wuxi 214026, Jiangsu, Peoples R China

[3] China Natl Petr Corp, Cent Hosp, Dept Pediat, Langfang 065000, Hebei, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

基金：

中国国家自然科学基金;

关键词：

STRAINS; GENE;

D O I：

10.1128/AAC.01563-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.

引用

页码：2158 / 2159

页数：2

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