The Ski protein can inhibit ligand induced RARα and HDAC3 degradation in the retinoic acid signaling pathway

被引：18

作者：

Zhao, Hong-Ling ^{[1
]}

Ueki, Nobuhide ^{[1
]}

Marcelain, Katherine ^{[2
]}

Hayman, Michael J. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] Univ Chile, Fac Med, ICBM, Programa Genet Humana, Santiago 7, Chile

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 01期

关键词：

Ski; RA; RAR alpha; HDAC3; Proteasome; Nuclear hormone signaling; HEMATOPOIETIC-CELLS; HORMONE RECEPTORS; 26S PROTEASOME; MICE LACKING; ONCOPROTEIN; PROTOONCOGENE; REPRESSION; COMPLEX; PHOSPHORYLATION; TRANSFORMATION;

D O I：

10.1016/j.bbrc.2009.03.141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent data has implicated the Ski protein as being a physiologically relevant negative regulator of signaling by retinoic acid (RA). The mechanism by which Ski represses RA signaling is unknown. Co-immunoprecipitation and immunofluorescence assay showed that Ski and RAR alpha are in the same complex in both the absence and presence of RA, which makes Ski different from other corepressors. We determined that Ski can stabilize RAR alpha and HDAC3. These results suggest that Ski represses RA signaling by stabilizing corepressor complex. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：119 / 124

页数：6

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