Cardiovascular remodelling in coronary artery disease and heart failure

被引:709
作者
Heusch, Gerd [1 ]
Libby, Peter [2 ]
Gersh, Bernard [3 ,4 ]
Yellon, Derek [5 ]
Boehm, Michael [6 ]
Lopaschuk, Gary [7 ]
Opie, Lionel [8 ]
机构
[1] Univ Klinikum Essen, Inst Pathophysiol, Essen, Germany
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA
[3] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA
[4] Mayo Clin, Coll Med, Rochester, MN USA
[5] UCL, Hatter Cardiovasc Inst, London, England
[6] Univ Klinikum Saarlandes, Innere Med Klin 3, Homburg, Germany
[7] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada
[8] Univ Cape Town, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, Western Cape, South Africa
关键词
ELEVATION MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR HYPERTROPHY; RANDOMIZED CONTROLLED-TRIAL; RENAL SYMPATHETIC DENERVATION; SMOOTH-MUSCLE CELLS; FAILING HUMAN HEART; MYOSIN HEAVY-CHAIN; REPERFUSION INJURY; FATTY-ACID; NO-REFLOW;
D O I
10.1016/S0140-6736(14)60107-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Remodelling is a response of the myocardium and vasculature to a range of potentially noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, compensatory, and adaptive but, when sustained, progresses to structural changes that become self-perpetuating and pathogenic. Remodelling involves responses not only of the cardiomyocytes, endothelium, and vascular smooth muscle cells, but also of interstitial cells and matrix. In this Review we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure, and we draw attention to potential avenues for innovative therapeutic approaches, including conditioning and metabolic strategies.
引用
收藏
页码:1933 / 1943
页数:11
相关论文
共 130 条
[1]   Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy [J].
Abozguia, Khalid ;
Elliott, Perry ;
McKenna, William ;
Phan, Thanh Trung ;
Nallur-Shivu, Ganesh ;
Ahmed, Ibrar ;
Maher, Abdul R. ;
Kaur, Kulvinder ;
Taylor, Jenny ;
Henning, Anke ;
Ashrafian, Houman ;
Watkins, Hugh ;
Frenneaux, Michael .
CIRCULATION, 2010, 122 (16) :1562-U56
[2]   Aldosteronism and peripheral blood mononuclear cell activation - A neuroendocrine-immune interface [J].
Ahokas, RA ;
Warrington, KJ ;
Gerling, IC ;
Sun, Y ;
Wodi, LA ;
Herring, PA ;
Lu, L ;
Bhattacharya, SK ;
Postlethwaite, AE ;
Weber, KT .
CIRCULATION RESEARCH, 2003, 93 (10) :E124-E135
[3]   Molecular and phenotypic effects of heterozygous, homozygous, and compound heterozygote myosin heavy-chain mutations [J].
Alpert, NR ;
Mohiddin, SA ;
Tripodi, D ;
Jacobson-Hatzell, J ;
Vaughn-Whitley, K ;
Brosseau, C ;
Warshaw, DM ;
Fananapazir, L .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2005, 288 (03) :H1097-H1102
[4]   Evidence for Cardiomyocyte Renewal in Humans [J].
Bergmann, Olaf ;
Bhardwaj, Ratan D. ;
Bernard, Samuel ;
Zdunek, Sofia ;
Barnabe-Heider, Fanie ;
Walsh, Stuart ;
Zupicich, Joel ;
Alkass, Kanar ;
Buchholz, Bruce A. ;
Druid, Henrik ;
Jovinge, Stefan ;
Frisen, Jonas .
SCIENCE, 2009, 324 (5923) :98-102
[5]   IMPROVED HEMODYNAMIC FUNCTION AND MECHANICAL EFFICIENCY IN CONGESTIVE-HEART-FAILURE WITH SODIUM DICHLOROACETATE [J].
BERSIN, RM ;
WOLFE, C ;
KWASMAN, M ;
LAU, D ;
KLINSKI, C ;
TANAKA, K ;
KHORRAMI, P ;
HENDERSON, GN ;
DEMARCO, T ;
CHATTERJEE, K .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (07) :1617-1624
[6]  
Böhm M, 2010, LANCET, V376, P886, DOI 10.1016/S0140-6736(10)61259-7
[7]   INCREASE OF GI-ALPHA IN HUMAN HEARTS WITH DILATED BUT NOT ISCHEMIC CARDIOMYOPATHY [J].
BOHM, M ;
GIERSCHIK, P ;
JAKOBS, KH ;
PIESKE, B ;
SCHNABEL, P ;
UNGERER, M ;
ERDMANN, E .
CIRCULATION, 1990, 82 (04) :1249-1265
[8]   C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling [J].
Bostroem, Pontus ;
Mann, Nina ;
Wu, Jun ;
Quintero, Pablo A. ;
Plovie, Eva R. ;
Panakova, Daniela ;
Gupta, Rana K. ;
Xiao, Chunyang ;
MacRae, Calum A. ;
Rosenzweig, Anthony ;
Spiegelman, Bruce M. .
CELL, 2010, 143 (07) :1072-1083
[9]   Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial [J].
Botker, Hans Erik ;
Kharbanda, Rajesh ;
Schmidt, Michael R. ;
Bottcher, Morten ;
Kaltoft, Anne K. ;
Terkelsen, Christian J. ;
Munk, Kim ;
Andersen, Niels H. ;
Hansen, Troels M. ;
Trautner, Sven ;
Lassen, Jens Flensted ;
Christiansen, Evald Hoj ;
Krusell, Lars R. ;
Kristensen, Steen D. ;
Thuesen, Leif ;
Nielsen, Soren S. ;
Rehling, Michael ;
Sorensen, Henrik Toft ;
Redington, Andrew N. ;
Nielsen, Torsten T. .
LANCET, 2010, 375 (9716) :727-734
[10]   Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice [J].
Bouhidel, Omar ;
Pons, Sandrine ;
Souktani, Richard ;
Zini, Roland ;
Berdeaux, Alain ;
Ghaleh, Bijan .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (04) :H1580-H1586