Bladder Cancer Biomarkers: Review and Update

被引：31
作者：
Ghafouri-Fard, Soudeh [1 ]
Nekoohesh, Leili [2 ]
Motevaseli, Elahe [2 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Adv Med Technol, Dept Med Biotechnol, Tehran, Iran
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 06期
关键词：
Bladder cancer; biomarker; diagnosis; prognosis; TRANSITIONAL-CELL CARCINOMA; UROTHELIAL CARCINOMA; PROMOTER METHYLATION; EXPRESSION PROFILE; DNA METHYLATION; URINE SAMPLES; BTA TRAK; DIAGNOSIS; MARKER; GENES;
D O I：
10.7314/APJCP.2014.15.6.2395
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
As the recurrence and mortality rates of bladder cancer are high, research is needed to find suitable biomarkers for early detection, evaluation of prognosis, and surveillance of drug responses. We performed a computerized search of the Medline/PubMed databases with the key words bladder cancer, biomarker, early detection, prognosis and drug response. Several markers were identified at DNA, RNA and protein levels with different sensitivities and specificities. Only a few of the potential bladder cancer biomarkers have been approved for clinical use. Efforts now should be concentrated on finding a panel of markers with acceptable sensitivity and specificity for early detection of bladder cancer.
引用
收藏
页码：2395 / 2403
页数：9
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