Enantiomeric Separation of Chiral Alcohols Using Novel Core-Shell Type Chiral Stationary Phase Coated with Helical Poly(diphenylacetylene) Derivative by High-Performance Liquid Chromatography

被引：3
|
作者：
Nishioka, Ryota [1 ]
Harada, Syuji [1 ]
Umehara, Kazuhiro [1 ]
机构：
[1] Sumika Chem Anal Serv Ltd, Osaka Lab, Tech Solut Headquarters, Konohana Ku, 1-135 Kasugade Naka 3 Chome, Osaka 5540022, Japan
来源：
CHROMATOGRAPHY | 2019年 / 40卷 / 03期
关键词：
Enantiomeric separation; Chiral stationary phase; Helical poly(diphenylacetylene); Chiral alcohol; Core-shell;
D O I：
10.15583/jpchrom.2019.019
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Enantiomeric separation ability on high-performance liquid chromatography (HPLC) of novel chiral stationary phase (CSP) was evaluated. A chiral selector of the CSP investigated in this study (SUMICHIRAL (TM) OA-SHELL P1) is one of helical poly(diphenylacetylene) derivatives which is coated on core-shell silica support. OA-SHELL P1 showed excellent chiral separation ability for a wide range of aromatic chiral alcohols and it was also effective for separation of some chiral carboxylic acids, ketones and lactones. It is considered to be a new option for enantiomeric separation of these chiral compounds. OA-SHELL P1 is used in normal phase mode with a mobile phase of simple composition and one of its features is easy method development. The analysis time is relatively short even with conventional HPLC system since a core-shell support with particle size of 2.6 mu m is used.
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页码：169 / 173
页数：5
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