I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]-quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C-H cross-dehydrogenative coupling

被引：71

作者：

Zhang, Zeyuan ^{[1
]}

Xie, Caixia ^{[1
]}

Tan, Xiaochen ^{[1
]}

Song, Gaolei ^{[1
]}

Wen, Leilin ^{[1
]}

Gao, He ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 08期

基金：

美国国家科学基金会;

关键词：

CATALYZED OXIDATIVE SYSTEM; IN-VITRO; MULTICOMPONENT SYNTHESIS; SELECTIVE METHOD; BONDS ADJACENT; IODINE; EFFICIENT; CYCLIZATION; AMINATION; ALKYNYLATION;

D O I：

10.1039/c5qo00124b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient I-2-catalyzed cascade coupling protocol was developed for the synthesis of pyrrolo[1,2-a]-quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp(3) and sp(2) C-H cross-dehydrogenative coupling. A nontoxic, readily available catalyst, I-2, and an oxidant, DMSO, were used in this metal-free process. The target compounds were obtained in good-to-excellent yields with a broad substrate scope.

引用

页码：942 / 946

页数：5

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