Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment

被引：76

作者：

Haycox, CL ^{[1
]}

Odland, PB ^{[1
]}

Olbricht, SM ^{[1
]}

Piepkorn, M ^{[1
]}

机构：

[1] BETH ISRAEL HOSP, DEPT DERMATOL, BOSTON, MA 02215 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1997年 / 37卷 / 03期

关键词：

D O I：

10.1016/S0190-9622(97)70146-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dermatofibrosarcoma protuberans (DFSP) is a rare, clinically challenging, soft tissue tumor. The main histologic differential of DFSP is usually a dermatofibroma, In 1990, the first report appeased demonstrating that cells of DFSP express the human progenitor antigen CD34 on their surface. Since then, there have been increasing reports of the usefulness of immunohistochemical staining with CD34 to differentiate DFSP from dermatofibroma and other soft tissue tumors. This literature is reviewed with special emphasis on the insights studies have provided into the histogenesis of DFSP. The literature demonstrating the practical applications of CD34 staining in the diagnosis and treatment of DFSP is also discussed.

引用

页码：438 / 444

页数：7

共 38 条

[1] CD34 AND FACTOR-XIIIA IN THE DIFFERENTIAL-DIAGNOSIS OF DERMATOFIBROMA AND DERMATOFIBROSARCOMA PROTUBERANS [J].