Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies

Background Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been synthetized. We aimed to systematically review and critically appraise the evidence on the association between leptospirosis and CKD. Methodology/Principal findings Observational studies with a control group were selected. Leptospirosis, confirmed with laboratory methods, and CKD also based on a laboratory assessment, were the exposures and outcomes of interest. The search was conducted in EMBASE, MEDLINE, Global Health, Scopus and Web of Science. Studies selected for qualitative synthesis were assessed for risk of bias following the Newcastle-Ottawa Scale. 5,981 reports were screened, and 2 (n = 3,534) were included for qualitative synthesis. The studies were conducted in Taiwan and Nicaragua; these reported cross-sectional and longitudinal estimates. In the general population, the mean estimated glomerular filtration rate (eGFR) was lower (p<0.001) in people testing positive for antileptospira antibodies (eGFR = 98.3) than in negative controls (eGFR = 100.8). Among sugarcane applicants with high creatinine, those who were seropositive had lower eGFR (mean difference: -10.08). In a prospective analysis, people with high antileptospira antibodies titer at baseline and follow-up, had worse eGFR (p<0.05). Conclusion Although the available evidence suggests there may be a positive association between leptospirosis and CKD, whereby leptospirosis could be a risk factor for CKD, it is still premature to draw conclusions. There is an urgent need for research on this association. Author summary Leptospirosis is an infection that can affect the kidneys acutely, though it seems that even after the acute infection there could be risk of a long-term impaired kidney function. The evidence on this matter is sparse and limited, thus the need to comprehensively seek, synthetize and appraise the available scientific literature. In so doing, this work has found preliminary evidence that leptospirosis may be associated with impaired kidney function as per eGFR. This work and findings strongly reveal that more research is needed to quantify and characterize the long-term risk of CKD among those who had had leptospirosis infection. The raising burden of non-communicable diseases paired with a still non-negligible burden of communicable and neglected tropical diseases in low- and middle-income countries, deserve the synergism of these two broad fields for the benefit of patients and population health.