Chlamydomonas Swims with Two "Gears" in a Eukaryotic Version of Run-and-Tumble Locomotion

被引：373

作者：

Polin, Marco ^{[1
]}

Tuval, Idan ^{[1
]}

Drescher, Knut ^{[1
]}

Gollub, J. P. ^{[1
,2
]}

Goldstein, Raymond E. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Appl Math & Theoret Phys, Cambridge CB3 0WA, England

[2] Haverford Coll, Dept Phys, Haverford, PA 19041 USA

来源：

SCIENCE | 2009年 / 325卷 / 5939期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

LEFT-RIGHT ASYMMETRY; CILIA; REINHARDTII; FLUID; FLOW;

D O I：

10.1126/science.1172667

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The coordination of eukaryotic flagella is essential for many of the most basic processes of life (motility, sensing, and development), yet its emergence and regulation and its connection to locomotion are poorly understood. Previous studies show that the unicellular alga Chlamydomonas, widely regarded as an ideal system in which to study flagellar biology, swims forward by the synchronous action of its two flagella. Using high-speed imaging over long intervals, we found a richer behavior: A cell swimming in the dark stochastically switches between synchronous and asynchronous flagellar beating. Three-dimensional tracking shows that these regimes lead, respectively, to nearly straight swimming and to abrupt large reorientations, which yield a eukaryotic version of the "run-and-tumble" motion of peritrichously flagellated bacteria.

引用

页码：487 / 490

页数：4

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