Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

被引：50

作者：

Sugiyama, Satoshi ^{[1
,2
,3
]}

Hong, Young-Joo ^{[1
,3
]}

Kasaragod, Deepa ^{[1
,3
]}

Makita, Shuichi ^{[1
,3
]}

Uematsu, Sato ^{[4
]}

Ikuno, Yasushi ^{[4
]}

Miura, Masahiro ^{[5
]}

Yasuno, Yoshiaki ^{[1
,3
]}

机构：

[1] Univ Tsukuba, Computat Opt Grp, Tsukuba, Ibaraki, Japan

[2] Tomey Corp, Nagoya, Aichi, Japan

[3] Computat Opt & Ophthalmol Grp, Tsukuba, Ibaraki, Japan

[4] Osaka Univ Hosp, Dept Ophthalmol, Suita, Osaka, Japan

[5] Tokyo Med Univ, Ibaraki Med Ctr, Ami, Ibaraki, Japan

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 12期

关键词：

POLARIZATION-SENSITIVE OCT; EXUDATIVE MACULAR DISEASES; NERVE-FIBER LAYER; IN-VIVO; PHASE RETARDATION; ANTERIOR SEGMENT; HIGH-SPEED; HUMAN RETINA; HUMAN CORNEA; COLLAGEN;

D O I：

10.1364/BOE.6.004951

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1-mu m wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines/s, and 6.6 mu m in tissue, respectively. Normal and pathologic eyes are examined and several clinical features are revealed, which includes high birefringence in the choroid and lamina cribrosa, and birefringent layered structure of the sclera. The theoretical details of the depth-localized birefringence imaging and conventional phase retardation imaging are formulated. This formulation indicates that the birefringence imaging correctly measures a depth-localized single-trip phase retardation of a tissue, while the conventional phase retardation can provide correct single-trip phase retardation only for some specific types of samples. (C) 2015 Optical Society of America

引用

页码：4951 / 4974

页数：24

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