Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder

被引：22

作者：

Sechi, Elia

Buciuc, Marina

Flanagan, Eoin P.

Pittock, Sean J.

Banks, Samantha A.

Lopez-Chiriboga, A. Sebastian

Bhatti, M. Tariq

Chen, John J.

机构：

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 47卷

关键词：

MOG; CSF; neuromyelitis optica spectrum disorder; NMOSD; oligoclonal bands; optic neuritis; NEUROMYELITIS-OPTICA;

D O I：

10.1016/j.msard.2020.102638

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated. Objective and Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. Results: White-blood-cell (>5/mm(3)) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy. Conclusions: CSF findings in MOGAD vary by attack phenotype and preceding treatment.

引用

页数：4

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