Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography

被引：24
作者：
Adhi, Mehreen [1 ,2 ,3 ,4 ]
Badaro, Emmerson [5 ]
Liu, Jonathan J. [2 ,3 ,4 ]
Kraus, Martin F. [6 ,7 ]
Baumal, Caroline R. [1 ]
Witkin, Andre J. [1 ]
Hornegger, Joachim [6 ,7 ]
Fujimoto, James G. [2 ,3 ,4 ]
Duker, Jay S. [1 ]
Waheed, Nadia K. [1 ]
机构：
[1] Tufts Univ, Sch Med, New England Eye Ctr, Boston, MA 02111 USA
[2] MIT, Dept Elect Engn, Cambridge, MA 02139 USA
[3] MIT, Dept Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[4] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[5] Fed Univ Brazil, Dept Ophthalmol, Sao Paulo, Brazil
[6] Univ Erlangen Nurnberg, Pattern Recognit Lab, D-91054 Erlangen, Germany
[7] Univ Erlangen Nurnberg, SAOT, D-91054 Erlangen, Germany
来源：
AMERICAN JOURNAL OF OPHTHALMOLOGY | 2016年 / 162卷
关键词：
POSTERIOR VITREOUS DETACHMENT; VITREOMACULAR TRACTION; MACULAR EDEMA; EPIRETINAL MEMBRANES; IN-VIVO; VITREOSCHISIS; VITRECTOMY;
D O I：
10.1016/j.ajo.2015.10.025
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
PURPOSE: To analyze the vitreoretinal interface in diabetic eyes using 3-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SSOCT). DESIGN: Prospective cross-sectional study. METHODS: Fifty-six diabetic patients (88 eyes) and 11 healthy nondiabetic controls (22 eyes) were recruited. " Up to 8 SSOCT volumes were acquired for each eye. A registration algorithm removed motion artifacts and merged multiple SSOCT volumes to improve signal. Vitreous visualization was enhanced using vitreous windowing method. RESULTS: Of 88 diabetic eyes, 20 eyes had no retinopathy, 21 eyes had nonproliferative diabetic retinopathy (NPDR) without macular edema, 20 eyes had proliferative diabetic retinopathy (PDR) without macular edema, and 27 eyes had diabetic macular edema (DME) with either NPDR or PDR. Thick posterior hyaloid relative to healthy nondiabetic controls was observed in 0 of 20 (0%) diabetic eyes without retinopathy, 4 of 21 (19%) eyes with NPDR, 11 of 20 (55%) eyes with PDR, and 11 of 27 (41%) eyes with DME (P = .0001). Vitreoschisis was observed in 6 of 22 (27%) healthy nondiabetic eyes, 9 of 20 (45%) diabetic eyes without retinopathy, 10 of 21 (48%) eyes with NPDR, 13 of 20 (65%) eyes with PDR, and 17 of 27 (63%) eyes with DME (P = .007). While no healthy nondiabetic controls and diabetic eyes without retinopathy had adhesions/pegs between detached posterior hyaloid and retina, 1 of 21 (4%), 11 of 20 (55%), and 11 of 27 (41%) eyes with NPDR, PDR, and DME, respectively, demonstrated this feature (P = .0001). CONCLUSION: SSOCT with motion-correction and vitreous windowing provides wide-field 3-dimensional information of vitreoretinal interface in diabetic eyes. This may be useful in assessing progression of retinopathy, planning diabetic vitreous surgery, and predicting treatment outcomes. (C) 2016 by Elsevier Inc. All rights reserved.
引用
收藏
页码：140 / 149
页数：10
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