Race and Ethnicity Influences Collection of Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood Progenitor Cells from Unrelated Donors, a Center for International Blood and Marrow Transplant Research Analysis

被引：27

作者：

Hsu, Jack W. ^{[1
]}

Wingard, John R. ^{[1
]}

Logan, Brent R. ^{[2
]}

Chitphakdithai, Pintip ^{[3
]}

Akpek, Gorgun ^{[4
]}

Anderlini, Paolo ^{[5
]}

Artz, Andrew S. ^{[6
]}

Bredeson, Chris ^{[7
]}

Goldstein, Steven ^{[8
]}

Hale, Gregory ^{[9
]}

Hematti, Peiman ^{[10
]}

Joshi, Sarita ^{[11
]}

Kamble, Rammurti T. ^{[12
]}

Lazarus, Hillard M. ^{[13
]}

O'Donnell, Paul V. ^{[14
]}

Pulsipher, Michael A. ^{[15
]}

Savani, Bipin N. ^{[16
]}

Schears, Raquel M. ^{[17
]}

Shaw, Bronwen E. ^{[18
]}

Confer, Dennis L. ^{[19
]}

机构：

[1] Univ Florida, Shands Canc Ctr, Gainesville, FL USA

[2] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[3] Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA

[4] Banner MD Anderson Canc Ctr, Gilbert, AZ USA

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[6] Univ Chicago Hosp, Chicago, IL 60637 USA

[7] Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada

[8] Univ Michigan, Ann Arbor, MI 48109 USA

[9] Childrens Hosp, St Petersburg, FL USA

[10] Univ Wisconsin, Hosp & Clin, Madison, WI 53792 USA

[11] Nationwide Childrens Hosp, Columbus, OH USA

[12] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[13] Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA

[14] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[15] Univ Utah, Sch Med, Primary Childrens Hosp, Salt Lake City, UT USA

[16] Vanderbilt Univ, Med Ctr, Nashville, TN 37235 USA

[17] Mayo Clin Rochester, Rochester, MN USA

[18] Anthony Nolan Res Inst, London, England

[19] Natl Marrow Donor Program, Minneapolis, MN USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 01期

关键词：

Mobilization; Granulocyte colony-stimulating factor (G-CSF); Ethnicity; Race; D-ENDOCRINE SYSTEM; BONE-MARROW; G-CSF; ALLOGENEIC TRANSPLANTATION; HEALTHY DONORS; YIELD; NEUTROPHIL; HYPERCHOLESTEROLEMIA; FILGRASTIM; PROTEASES;

D O I：

10.1016/j.bbmt.2014.10.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Little information exists on the effect of race and ethnicity on collection of peripheral blood stem cells (PBSC) for allogeneic transplantation. We studied 10,776 donors from the National Marrow Donor Program who underwent PBSC collection from 2006 to 2012. Self-reported donor race/ethnic information included Caucasian, Hispanic, Black/African American (AA), Asian/Pacific Islander (API), and Native American (NA). All donors were mobilized with subcutaneous filgrastim at an approximate dose of 10 mu g/kg/day for 5 days. Overall, AA donors had the highest median yields of mononuclear cells per liter and CD34(+) cells per liter of blood processed (3.1 x 10(9) and 44 x 10(6), respectively), whereas Caucasians had the lowest median yields at 2.8 x 10(9) and 33.7 x 10(6), respectively. Multivariate analysis of CD34(+) per liter mobilization yields using Caucasians as the comparator and controlling for age, gender, body mass index, and year of apheresis revealed increased yields in overweight and obese AA and API donors. In Hispanic donors, only male obese donors had higher CD34(+) per liter mobilization yields compared with Caucasian donors. No differences in CD34(+) per liter yields were seen between Caucasian and NA donors. Characterization of these differences may allow optimization of mobilization regimens to allow enhancement of mobilization yields without compromising donor safety. (C) 2015 American Society for Blood and Marrow Transplantation.

引用

页码：165 / 171

页数：7

共 33 条

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