Mycobacterium tuberculosis, the causative agent of tuberculosis, drives the formation of granulomas, structures in which both immune cells and the bacterial pathogen cohabit. The most abundant cells in granulomas are macrophages, which contribute as both cells with bactericidal activity and as targets for M. tuberculosis infection and proliferation during the entire course of infection. The mechanisms and factors involved in the regulation and control of macrophage microenvironment-specific polarization and plasticity are not well understood, as some granulomas are able to control bacteria growth and others fail to do so, permitting bacterial spread. In this issue of the European Journal of Immunology, Venkatasubramanian etal. [Eur. J. Immunol. 2016. 46: 464-479] show that mice lacking the tissue factor gene in myeloid cells have augmented M. tuberculosis growth and increased inflammation in the lungs. This suggests that tissue factor, an initiator of coagulation, is important for the generation of fibrin, which supports granuloma formation. This article demonstrates for the first time the involvement of tissue factor in inducing effective immunity against M. tuberculosis, and sheds new lights on the complex interplay between host inflammatory response, the coagulation system, and the control of M. tuberculosis infection.
机构:
Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USAUniv Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA 15260 USA
Chan, J.
;
Lin, P. L.
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Univ Pittsburgh, Childrens Hosp, Div Infect Dis, Dept Pediat, Pittsburgh, PA 15260 USAUniv Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA 15260 USA
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Hagemann, Thorsten
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Lawrence, Toby
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Lawrence, Toby
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McNeish, Iain
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Ctr Mol Oncol, Inst Canc, London EC1M 6BQ, England
CR UK Clin Canc Ctr, London EC1M 6BQ, England
Barts & London Queen Marys Sch Med & Dent, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
McNeish, Iain
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Charles, Kellie A.
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Charles, Kellie A.
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Kulbe, Hagen
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Kulbe, Hagen
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Thompson, Richard G.
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Thompson, Richard G.
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Robinson, Stephen C.
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Robinson, Stephen C.
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Balkwill, Frances R.
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
机构:
Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USAUniv Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA 15260 USA
Chan, J.
;
Lin, P. L.
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h-index: 0
机构:
Univ Pittsburgh, Childrens Hosp, Div Infect Dis, Dept Pediat, Pittsburgh, PA 15260 USAUniv Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA 15260 USA
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Hagemann, Thorsten
;
Lawrence, Toby
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Lawrence, Toby
;
McNeish, Iain
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Mol Oncol, Inst Canc, London EC1M 6BQ, England
CR UK Clin Canc Ctr, London EC1M 6BQ, England
Barts & London Queen Marys Sch Med & Dent, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
McNeish, Iain
;
Charles, Kellie A.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Charles, Kellie A.
;
Kulbe, Hagen
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h-index: 0
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Kulbe, Hagen
;
Thompson, Richard G.
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h-index: 0
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Thompson, Richard G.
;
Robinson, Stephen C.
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h-index: 0
机构:
Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England
Robinson, Stephen C.
;
Balkwill, Frances R.
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Ctr Canc Inflammat, London EC1M 6BQ, EnglandCtr Canc Inflammat, London EC1M 6BQ, England